This is a single-center cohort study aimed to describe the urinary excretion kinetics of gadolinium contrast agents (Gd-CAs). Patients with a prescription for injected MRI are invited to participate in the study. If they agree, blood and urine samples are collected before Gd-CAs injection, and urine samples are collected between 0- and two-and-a-half-hours post-injection of Gd-CAs.
over 18 years of age
with a prescription for MRI with gadolinium-based contrast agents (Gd-CAs) injection validated by a radiologist
affiliated with a health insurance plan
have signed an informed consent form
with known allergy to gadolinium-based contrast agents (Gd-CAs)
with known severe renal impairment (GFR < 30 mL/min)
on dialysis
with urinary incontinence
Single group
biological samples collection
Other interventionUrine samples are collected before Gd-CAs injection, and between 0- and two-and-a-half-hour post-injection of Gd-CAs.
Urinary excretion of gadolinium-based contrast agents (Gd-CAs)
Describe the kinetics of urinary excretion of GdCAs during the 2H30 following gadoline contrast injection in patients undergoing injected MRI at the Mercy Hospital Medical Imaging Department. The cumulative quantity of gadolinium-based contrast agents (Gd-CAs) (mg) mesured in urine during spontaneous micturition between 0 and 2H30 after injection of gadoline contrast medium and during micturition on demand at 2.30 h. The amount of Gd present in the urine (directly associated with the presence of Gd-CAs) is determined by inductively coupled plasma mass spectrometry (ICPMS). Urine concentrations are expressed in µg/L. Taking into account the volume of urine collected, the quantity of Gd is calculated and expressed in mg. This quantity is then expressed as a percentage of the quantity of injected-Gd-CAs.
Renal function
Glomerular filtration rate (GFR: mL/min) estimated by the CKD-EPI method on the day of MRI.
Volume of beverages
Volume of beverages drunk (mL) after each micturition, declared by the patient since Gd-CAs injection, to the nearest 100 mL.
Time to first spontaneous micturition
Duration (in minutes) between time of Gd-CAs injection and time of first spontaneous micturition.
Study refusal rate
Percentage (%) of study refusal
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Centre Hospitalier Régional Metz-Thionville
Lead sponsor
University of Lorraine
Collaborator
