LA Strain in Predicting Early Complication in STEMI After PPCI
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorAssiut University
About this trial
The goal of this observational study To evaluate the predictive value of left atrial strain for in-hospital outcomes in patients with ST-segment elevation myocardial infarction undergoing PPCI. The main questions it aims to answer are:
Is low parameters of left atrial strain associated early complication ? What is the correlation between LA strain parameters and conventional echocardiographic indices of left ventricular systolic and diastolic function ? Is there more affection to LA strain in certain territory over the others ? What is the correlation between LA strain and LA volume index across infarct territories ? Does LA strain Correlate with TAPSE and PASP to evaluate right-heart interactions ?
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Adults aged ≥18 years.
Diagnosed with ST-segment elevation myocardial infarction (STEMI) according to current ESC/AHA criteria
Underwent successful primary percutaneous coronary intervention (PPCI) within 12 hours of symptom onset.
Sinus rhythm on admission .
Disqualifiers
Previous myocardial infarction or prior PCI/CABG.
Patients known to have atrial fibrillation or other sustained supraventricular arrhythmias.
Significant valvular heart disease (severe stenosis or regurgitation).
Congenital heart disease or cardiomyopathy (hypertrophic, dilated, restrictive).
Trial population
patients diagnosed with ST-segment elevation myocardial infarction and Underwent successful primary percutaneous coronary intervention and control group to provide baseline parameters for comparing LA strain and other echocardiographic parameters
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
2D echocardiography
Other interventionLA strain by 2D echocardiographic speckle tracking analysis
Treatment groups
135 Participants
are divided into 3 treatment groupsGroup A: group normal strain1 intervention
Group B: group low strain1 intervention
Group C: group control1 intervention
Trial outcomes
Primary outcomes
1
the predictive value of left atrial strain for detecting incidence of in-hospital outcomes in patients with ST-segment elevation myocardial infarction undergoing primary PCI.
To evaluate the predictive value of left atrial strain for hospitalized patients with ST-segment elevation myocardial infarction undergoing primary PCI as regarding * All-cause in-hospital mortality * New/worsening heart failure requiring IV therapy or ICU care * Cardiogenic shock (requiring inotropes or mechanical support) * Sustained ventricular arrhythmia (VT/VF)
Time frame
up to one weekSecondary outcomes
1
correlation with other parameters
Correlation between LA strain parameters (reservoir, conduit, and contractile strain) by speckle tracking echocardiography and conventional echocardiographic indices of left ventricular (LV) systolic and diastolic function (LVEF, LVGLS , E/e', LAVI).
Time frame
up to one week2
LA strain across different territories
Compare LA strain (reservoir, conduit, contractile) by speckle tracking echocardiography between anterior (LAD-territory) vs inferior (RCA/LCx-territory) STEMI as which territory would have more affection to LA strain
Time frame
up to one week3
LA stain vs LAVI
Correlation between LA strain and LA volume index (LAVI) across infarct territories
Time frame
up to one week4
LA strain and right side
Correlate LA strain with TAPSE and PASP to evaluate right-heart interactions
Time frame
up to one weekSponsors and contacts
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Source ClinicalTrials.gov
This trial is not recruiting at the moment. You can still explore other options: