Background:
\- Malaria is a disease that affects many people in African countries. It is caused by germs that are spread by mosquito bites. It can be fatal if not diagnosed and treated right away. Children younger than 5 and pregnant women are most at risk to get malaria. Researchers want to create a vaccine that will prevent malaria infection during pregnancy.
Objectives:
\- To create a vaccine that will prevent malaria infection during pregnancy. To assess possible vaccines using in-vitro tests with parasites taken from pregnant women.
Eligibility:
\- Pregnant women ages 15-25
Design:
* The study site is an area in Mali, West Africa. * Participants: * Will have blood drawn. * Will give consent for the blood sample to be used for future research. * May have a physical exam. * Participants who have malaria or anemia will get treatment.
Pregnant women aged 15-25 years
Able to provide consent for self
Malaria positive by rapid diagnostic test (RDT)
Severe anemia defined as HGB<7 gr/dL, that may be worsened by 10 mL phlebotomy
Conditions that in the judgment of the investigator could increase the risk to the volunteer
Prior enrollment to the study during the same pregnancy
Pregnant women age 15-25 years presenting for antenatal consultations or delivery at health centers or hospital in Ouelessebougou and neighboring districts@@@@@@
Case-only
Cross-sectional
Not listed
Measure of functional activity of animal IgG against vaccine candidates to block binding of fresh pregnancy malaria isolates to the placental receptor CSA
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