Lactate Kinetics in Septic Shock
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorKarolinska University Hospital
About this trial
Lactate kinetics will be studied in hospitalized septic patients using a bolus injection of stable isotopically labeled lactate.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Sepsis
Age >17 years
Arterial catheter
Lactate > 2 mmol at any time point prior to inclusion
Disqualifiers
Mitochondrial defect
Degenerative muscle disease
Terminal liver failure
Trial design
Design model
Single group
Treatments tested in this trial
Isotopically labeled lactate
Other interventionA bolus dose of isotopically labeled lactate is given and blood samples from existing catheters are drawn
Treatment groups
60 Participants
are divided into 1 treatment groupGroup A: All patientsExperimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
Whole body rate of appearance of lactate
The total amount of lactate produced per unit of time
Time frame
2 hoursSecondary outcomes
1
Clearance of lactate
Amount of plasma that is cleared from lactate per unit of time
Time frame
2 hoursSponsors and contacts
Click on the lead sponsor to view all of their trials.
Karolinska University Hospital
Lead sponsor
Region Stockholm
Collaborator
European Society of Intensive Care Medicine
Collaborator
The Scandinavian Society of Anaesthesiology and Intensive Care Medicine (SSAI)
Collaborator
Source ClinicalTrials.gov