LAnguage-Motor Imagery Circuits to Improve Motor Learning and Language Comprehension

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-40
SponsorUniversity Hospital, Grenoble

About this trial

Recent evidence suggests that cognitive systems do not operate in isolation but interact within broader networks, thus opening new avenues for fundamental and clinical research. An illustrative example is the interaction between language comprehension and motor representations. For instance, motor training (e.g., sports, origami training) can facilitate action verb recognition, whereas motor deficits (e.g., upper limb immobilization) can hinder the processing of action language. Similarly, action language has been shown to affect motor performance. These effects are attributed to an implicit form of motor imagery, an automatic simulation of motor experience (without actual movement) evoked by action words. Interestingly, literature supports the idea that the motor simulations used for imagining an action are also engaged during the reading of action language, leading to similar neurophysiological and behavioral changes in both processes. However, questions remain about the similarity of the simulations generated by motor imagery and action language. This project, encompassing three experimental sequences, aims to address these questions to achieve significant scientific advancements in both theoretical and applied domains.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

persons who have given written consent,

healthy subjects

subjects reading and understanding French

right-handed,

Disqualifiers

Existence of a severe general medical condition: cardiac, respiratory, hematological, renal, hepatic, cancerous,

Regular use of anxiolytics, sedatives, antidepressants, neuroleptics,

Characterized psychiatric pathology,

Ingestion of alcohol prior to the examination,

Trial population

Subjects will be aged between 18 and 40, reading and understanding French, with no neurological or psychiatric disorders, no uncorrected vision deficits, and meeting all MRI or TMS examination criteria. they were recruited at the University of Burgundy (TMS measures only) and the University of Grenoble Alpes (fMRI measures only).

Trial design

Design model

Case-control

Time perspective

Prospective

Treatments tested in this trial

  • Motor imagery

    Other intervention

    Participants were asked to imagine arm or foot movements.

  • Action reading

    Other intervention

    Participants were asked to read sentences involving arm or foot movements

  • Motor localizer

    Other intervention

    Participants were asked to perform arm or foot movements

Treatment groups

105 Participants
are divided into 5 treatment groups
Group A: TMS Experimental group2 interventions
Group B: fMRI Experimental group3 interventions
Group C: Experimental ccPAS group2 interventions
Group D: Sham ccPAS group2 interventions
Group E: control group2 interventions

Trial outcomes

Primary outcomes

1

Level of corticospinal excitability

this is a physiological response obtained by transcranial magnetic pulses (TMS). This is an indicator of the excitability of the motor system, which can be used at rest or during various cognitive tasks (motor imagery or action reading).

Time frame
1 hour and 30 minutes
2

Cortical activation (BOLD signal)

this is a cortical response obtained via a fMRI. This is an indicator of the brain activity, which can be used at rest or during motor and cognitive tasks (motor imagery or action reading).

Time frame
1 hour

Secondary outcomes

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University Hospital, Grenoble

Lead sponsor

University of Burgundy

Collaborator