About this trial
Recent evidence suggests that cognitive systems do not operate in isolation but interact within broader networks, thus opening new avenues for fundamental and clinical research. An illustrative example is the interaction between language comprehension and motor representations. For instance, motor training (e.g., sports, origami training) can facilitate action verb recognition, whereas motor deficits (e.g., upper limb immobilization) can hinder the processing of action language. Similarly, action language has been shown to affect motor performance. These effects are attributed to an implicit form of motor imagery, an automatic simulation of motor experience (without actual movement) evoked by action words. Interestingly, literature supports the idea that the motor simulations used for imagining an action are also engaged during the reading of action language, leading to similar neurophysiological and behavioral changes in both processes. However, questions remain about the similarity of the simulations generated by motor imagery and action language. This project, encompassing three experimental sequences, aims to address these questions to achieve significant scientific advancements in both theoretical and applied domains.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
persons who have given written consent,
healthy subjects
subjects reading and understanding French
right-handed,
Disqualifiers
Existence of a severe general medical condition: cardiac, respiratory, hematological, renal, hepatic, cancerous,
Regular use of anxiolytics, sedatives, antidepressants, neuroleptics,
Characterized psychiatric pathology,
Ingestion of alcohol prior to the examination,
Trial population
Subjects will be aged between 18 and 40, reading and understanding French, with no neurological or psychiatric disorders, no uncorrected vision deficits, and meeting all MRI or TMS examination criteria. they were recruited at the University of Burgundy (TMS measures only) and the University of Grenoble Alpes (fMRI measures only).
Trial design
Case-control
Prospective
Treatments tested in this trial
Motor imagery
Other interventionParticipants were asked to imagine arm or foot movements.
Action reading
Other interventionParticipants were asked to read sentences involving arm or foot movements
Motor localizer
Other interventionParticipants were asked to perform arm or foot movements
Treatment groups
Trial outcomes
Primary outcomes
Level of corticospinal excitability
this is a physiological response obtained by transcranial magnetic pulses (TMS). This is an indicator of the excitability of the motor system, which can be used at rest or during various cognitive tasks (motor imagery or action reading).
Cortical activation (BOLD signal)
this is a cortical response obtained via a fMRI. This is an indicator of the brain activity, which can be used at rest or during motor and cognitive tasks (motor imagery or action reading).
Sponsors and contacts
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University Hospital, Grenoble
Lead sponsor
University of Burgundy
Collaborator