Language Outcomes, Mechanisms, and Trajectories in Adults With and Without Developmental Language Disorder

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age30-35
SponsorUniversity of Iowa

About this trial

The investigators' overall objective is to characterize the long-term outcomes of Developmental Language Disorder (DLD) in adulthood and to identify specific cognitive mechanisms mediating these outcomes. To address their objectives, the investigators utilize a large, pre-existing dataset and participant pool from one of the most comprehensive examinations of DLD to date: the Iowa Longitudinal Study. The investigators will re-recruit subjects with DLD and with typical language from this historic cohort, who are now adults (30-35 years old). In Aim 1, the investigators will use measures from kindergarten through 10th grade and collect new outcome measures in adulthood to characterize the long-term outcomes of DLD. The investigators predict that adults with DLD will diverge from adults with TL in language skills that are more complex and higher-level language skills that are important for communication in the workplace. Further, the investigators predict a fanning effect: some children with DLD will "catch up" to their TL peers in adulthood, some will show evidence of a decline, and others will show stable trajectories. In Aim 2, the investigators measure real-time competition across written and spoken language using eye-tracking. According to speed of processing accounts adults with DLD may be slower than their TL peers to activate competitors and targets. According to working memory accounts adults with DLD will show sustained competitor activation. Further, the investigators predict that measures related to the dynamics of competition (speed of activation and timing of competitor suppression) will account for variation in language outcomes in adults.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Adults with Developmental Language Disorder (DLD) and those with typical language (TL) between the ages of 28 and 40 years who participated in the Iowa Longitudinal Study(NIH-DC-19-90 & P50 DC002746; IRB# 200106051, "Collaboration on Specific Language Impairment".)

Aged 30-35

Normal or corrected to normal vision

Normal hearing

Disqualifiers

history of brain injury

history of neural developmental disabilities

not monolingual

Trial population

Approximately 150 adults with Developmental Language Disorder (DLD) and 250 adults with typical language (TL) will participate in this project. Participants will be between the ages of 30 and 34 years at time of enrollment. Participants will be drawn from a large cohort of adults with and without DLD who participated in the Iowa Longitudinal Study (an extensive longitudinal follow-up of an epidemiological study of DLD)

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

  • Eye-Tracking in Visual World Paradigm

    Behavioral

    Participants complete six eye tracking tasks. They see images on a computer screen are tasked with finding a specific picture or saying a specific word (target). We track their eye movements to the visual representations of the target compared with their eye movements to visual representations of items that are similar to the target.

Treatment groups

400 Participants
are divided into 2 treatment groups
Group A: Developmental Language Disorder1 intervention
Group B: Typically Developing1 intervention

Trial outcomes

Primary outcomes

1

Eye movements

Participant are presented with images, and here words referring two one of the images while their eye movements are tracked. We measure the proportion fixations to the target image and distractor images over time. The measurement tool we are using is an eye-tracker (EyeLink portable duo) Note this is BESH, no intervention

Time frame
2 hours

Secondary outcomes

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University of Iowa

Lead sponsor

National Institutes of Health (NIH)

Collaborator

National Institute on Deafness and Other Communication Disorders (NIDCD)

Collaborator