About this trial
Late subclinical cardiovascular disease in testicular cancer survivors exposed to cisplatin-based chemotherapy and bone marrow transplant
Eligibility criteria
Qualifiers
Patients >18 years of age
Patients will be recruited only if cancer-free at clinical evaluation time.
For the cases a confirmed TC diagnosis who received one or more cycles of CBCT-based chemotherapies (CBCT group, Arm 2)
For the cases with a confirmed TC diagnosis who received one or more cycles of CBCT-based chemotherapies and underwent BMT for relapsed refractory disease (CBCT & BMT group, Arm 3).
Disqualifiers
Prior known myocardial infarction (MI), atherosclerotic cardiovascular disease (ASCVD)
Significant renal disease (GFR<40)
Allergy to iodinated contrast
Antecedent chemotherapy for another primary cancer.
Trial design
Treatments tested in this trial
- Lipid profile
- Coronary artery assessment
- Hormone levels for hypogonadism
Treatment groups
Sponsors and collaborators
Indiana University
Lead sponsor
National Institutes of Health (NIH)
Collaborator
JDS Foundation Testis Cancer Clinical Trials Support Fund
Collaborator