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Latin American Testing of the Inventory for Risk in Suicidal Crisis Syndrome (LATIR-SCS)

ConditionSuicidal Crisis
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorUniversity Diego Portales

About this trial

The goal of this observational validation study is to assess the psychometric properties of the Spanish versions of the Suicide Crisis Inventory-Revised (SCS-2) and the Suicidal Crisis Syndrome Checklist (SCS-C) in adults recently hospitalized for suicidal behavior in Chile. The study aims to determine whether the Spanish versions of the SCS-2 and SCS-C demonstrate adequate internal consistency, construct validity, interrater reliability, and test-retest stability, and whether these tools validly assess imminent suicide risk in a Spanish-speaking psychiatric population. Clinical assessments using the SCS-2 and SCS-C will be compared with established diagnostic and functional measures, including the Mini International Neuropsychiatric Interview (MINI), the Sheehan Disability Scale (SDS), and the Sheehan Suicidality Tracking Scale (S-STS), to evaluate convergent and discriminant validity. Participants will complete the SCS-2 and SCS-C at both admission and discharge from a psychiatric intensive care unit, undergo structured interviews and functional assessments, be evaluated by two independent raters for interrater reliability, and be reassessed within a short time interval to measure test-retest reliability. Follow-up contacts at 7 and 30 days post-discharge will be used to assess suicidal behavior outcomes. This is the first study to culturally adapt and validate these suicide-specific instruments in Latin America.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Age ≥ 18 years

Currently hospitalized in the Psychiatric Intensive Care Unit (UHCIP) at Complejo Asistencial Dr. Sótero del Río (CASR)

Deliberate self-inflicted violence with actual or potential injury and explicit or implicit suicidal intent

Preparatory behaviors for suicide

Disqualifiers

Presence of severe psychotic symptoms

Qualitative or quantitative disturbance of consciousness (e.g., delirium, coma)

Severe psychomotor agitation requiring mechanical restraint

Inability to understand or complete study procedures (e.g., due to cognitive impairment or language barriers)

Trial population

The study population consists of adult psychiatric inpatients (≥18 years old) hospitalized in the Psychiatric Intensive Care Unit (UHCIP) of the Complejo Asistencial Dr. Sótero del Río (CASR), Santiago, Chile. All participants are admitted due to a recent suicidal event, including suicide attempts, preparatory behaviors, interrupted or aborted attempts, or suicidal ideation requiring emergency care. The sample includes individuals with diverse psychiatric diagnoses and varying levels of acute suicide risk. Participants must be clinically stable, capable of providing informed consent, and fluent in Spanish. The population is representative of high-risk individuals typically seen in public psychiatric emergency settings in Latin America.

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

  • Suicidal Crisis Syndrome Checklist (SCS-C)

    Diagnostic test

    The Suicidal Crisis Syndrome Checklist (SCS-C) is a clinician-rated tool designed to diagnose Suicidal Crisis Syndrome (SCS), a suicide-specific state associated with imminent risk. It includes Criterion A (entrapment)-a required symptom-and Criterion B, which requires at least one symptom from each of four domains: affective disturbance, loss of cognitive control, hyperarousal, and social withdrawal. The checklist offers a structured assessment for identifying acute suicide risk, complementing traditional risk evaluations.

  • Suicide Crisis Inventory-Revised (SCS-2)

    Diagnostic test

    The Suicide Crisis Inventory-Revised (SCS-2) is a 61-item self-report scale developed to assess the severity of Suicidal Crisis Syndrome (SCS), a clinical state associated with imminent suicide risk. Items are rated on a Likert scale and grouped into five empirically derived factors: entrapment, affective disturbance, loss of cognitive control, hyperarousal, and social withdrawal. The SCS-2 has shown strong internal consistency and predictive validity for suicidal behavior within weeks of discharge. It is currently undergoing cultural adaptation and psychometric validation in Spanish for use in high-risk psychiatric populations in Chile.

Treatment groups

60 Participants
are divided into 2 treatment groups
Group A: SCS+ Cohort2 interventions
Group B: SCS- Cohort2 interventions

Trial outcomes

Primary outcomes

1

Suicidal Event Within 30 Days Post-Discharge

Description: Occurrence of a suicidal event within 30 days after discharge, defined as any of the following: 1. Deliberate self-inflicted violence resulting in actual or potential injury, with explicit or implicit evidence of suicidal intent; 2. Preparatory behaviors for suicide; 3. Aborted suicide attempts; 4. Interrupted suicide attempts; or 5. Suicidal ideation leading to emergency consultation or referral. Assessment Method: Patient phone follow-up and review of clinical records Measure Type: Clinical outcome (binary: presence/absence of suicidal event)

Time frame
30 days post-discharge

Secondary outcomes

1

Suicidal Event Within 7 Days Post-Discharge

Description: Occurrence of a suicidal event within 7 days after discharge, defined as any of the following: 1. Deliberate self-inflicted violence resulting in actual or potential injury, with explicit or implicit evidence of suicidal intent; 2. Preparatory behaviors for suicide; 3. Aborted suicide attempts; 4. Interrupted suicide attempts; or 5. Suicidal ideation leading to emergency consultation or referral. Assessment Method: Patient phone follow-up and review of clinical records Measure Type: Clinical outcome (binary: presence/absence of suicidal event)

Time frame
7 days post-discharge
2

Convergent Validity with the Sheehan Suicidality Tracking Scale (S-STS)

Description: Strength of association between total scores on the Spanish SCS-2, SCS-C and S-STS, a validated measure of suicidal risk severity. Assessment Method: Pearson or Spearman correlation coefficients Measure Type: Psychometric validity (convergent)

Time frame
Baseline
3

Convergent Validity with the Sheehan Disability Scale (SDS)

Description: Correlation between SCS-2 total scores, SCS-C and functional impairment measured by the SDS in three domains: work, social life, and family responsibilities. Assessment Method: Pearson or Spearman correlations Measure Type: Psychometric validity (convergent)

Time frame
Baseline
4

Discriminant Validity with Psychiatric Diagnoses on the MINI

Description: Ability of the SCS-2 and SCS-C to discriminate between participants with and without current psychiatric diagnoses commonly associated with elevated suicide risk, as assessed by the Mini International Neuropsychiatric Interview (MINI). Diagnoses of interest include: Major Depressive Episode Post-Traumatic Stress Disorder (PTSD) Panic Disorder Assessment Method: Point-biserial correlations and group comparisons Measure Type: Psychometric validity (discriminant)

Time frame
Baseline

Other outcomes

Sponsors and contacts

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University Diego Portales

Lead sponsor

Hospital Dr Sotero del Rio

Collaborator

Source ClinicalTrials.gov
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