This study will develop a whole-of-body markerless tracking method for measuring the motion of the tumour and surrounding organs during radiation therapy to enable real-time image guidance.
Routinely acquired patient data will be used to improve the training, testing and accuracy of a whole-of-body markerless tracking method. When the markerless tracking method is sufficiently advanced, according to the PI of each of the data collection sites, the markerless tracking method will be run in parallel to, but not intervening with, patient treatments during data acquisition.
Will receive radiation therapy for brain, breast, head and neck, kidney, liver, pancreas, prostate, spine cancer treatment or cardiac arrhythmia treatment at a participating centre.
Will receive CT planning, and a cone beam CT scan for at least one fraction of radiation therapy.
Will receive intrafraction x-ray imaging for the liver, pancreas, prostate, spine cancer treatment or cardiac arrhythmia treatment. As intrafraction imaging is not common standard of care for brain, breast, head and neck and kidney cancer treatments there is no requirement to have intrafraction x-ray imaging data for these anatomical sites.
Provides written informed consent.
Less than 18 years of age
300 participants, at least 30 from each of nine cohorts of anatomical sites receiving radiation therapy treatment. Eight cohorts include: those being treated for cancer at anatomical sites of brain, head and neck, breast, liver, pancreas, kidney, prostate, spine; those being treated for cardiac arrhythmia.
Cohort
Prospective
Not listed
9
Trial groupsSee each trial group below.
Accuracy of markerless tracking
Proportion of markerless tracking within 5 mm of the ground truth for each of nine anatomical sites (cohorts)
Clinical acceptability of markerless tracking system
Proportion of radiation therapists considering the markerless tracking system acceptable using a survey
Click on the lead sponsor to view all of their trials.
University of Sydney
Lead sponsor
Princess Alexandra Hospital, Brisbane, Australia
Collaborator
Calvary Mater Newcastle, Australia
Collaborator
Western Sydney Local Health District
Collaborator
Austin Health
Collaborator
Peter MacCallum Cancer Centre, Australia
Collaborator
