Leipzig Adipose Tissue Childhood Cohort
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
AgeNot listed
SponsorUniversity of Leipzig
About this trial
In this study the investigators hypothesize that pathological alterations in adipose tissue biology already occur during the development and progression of obesity in children and adolescents. The investigators aim to identify and characterize mechanisms and molecular targets that affect the development of adipose tissue and ensuing obesity in childhood and adolescence.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
body weight: 3000 g - 180 kg
suitable surgical procedure
signed informed consent by the guardians and the study participant, if older 12 years
Disqualifiers
severe chronic and inflammatory diseases
acute or chronic infections
oncological diseases
clotting disorders
Trial population
children and adolescents undergoing surgery at the University Hospital Leipzig
Trial design
Design model
Cohort
Time perspective
Cross-sectional
Treatments tested in this trial
Not listed
Trial groups
1,000 Participants
are grouped into 1 trial groupGroup A: lean and obese children and adolescents
Trial outcomes
Primary outcomes
1
Adipose tissue dysfunction
Adipose tissue dysfunction is assessed by evaluation of adipocyte size and number (hypertrophy vs. hyperplasia), adipocyte proliferation and differentiation, (lipid) cellular metabolism, inflammation, gene expression, fibrosis, and others; the association of AT dysfunction with clincial phenotype will be assessed
Time frame
10 yearsSecondary outcomes
1
Presence of brown adipose tissue (BAT)
Adipose tissue samples will be evaluated for the presence of BAT on histological and molecular level and association with clinical phenotype will be investigated
Time frame
10 years2
Inflammation of adipose tissue
Inflammation will be assessed by evaluating macrophage infiltration on histological and molecular expression level. Also, association with clinical phenotype will be assessed.
Time frame
10 yearsSponsors and contacts
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Source ClinicalTrials.gov