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LIA vs. LIA + ACB-iPACK Block for Total Knee Arthroplasty

ConditionsNerve BlockNeuromuscular Blockade
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-85
SponsorWomen's College Hospital

About this trial

LIA is the mainstay of postoperative analgesia in patients having knee arthroplasty. The combination of ACB-iPACK blocks has also been proposed as an effective analgesic modality for total knee arthroplasty. However, whether combining these two modalities yields any important incremental analgesic benefit remains unclear. The investigators hypothesized that the addition of ACB and iPACK blocks to LIA will yield clinically important analgesic benefits compared to LIA alone in patients having total knee arthroplasty.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

ASA classification I-III

BMI < 35 kg/m2

Having elective unilateral total knee arthroplasty

Disqualifiers

Bilateral knee surgery.

Pre-existing neurological deficit or peripheral neuropathy in the lower the lower limbs

Severe, poorly controlled cardiac conditions, significant arrhythmias, severe valvular heart diseases

Severe, poorly controlled respiratory conditions (severe COPD, severe interstitial lung disease, severe / poorly controlled asthma)

Trial design

Design model

Parallel

Treatments tested in this trial

  • Local infiltration analgesia

    Procedure/Surgery

    Procedure: Local infiltration analgesia performed by surgeons.

  • Ultrasound-guided adductor canal block

    Procedure/Surgery

    Procedure: Ultrasound-guided adductor canal and iPACK blocks performed by anesthesiologists preoperatively.

Treatment groups

60 Participants
are divided into 2 treatment groups
Group A: Local infiltration analgesiaExperimental treatment 1 intervention
Group B: Local infiltration analgesia + ACB-iPACK blockActive comparator 2 interventions

Trial outcomes

Primary outcomes

1

Postoperative pain at rest

Area under the curve

Time frame
over the first 24 hours
2

Quality of recovery (QoR-15)

Quality of Recovery (QR15) scores at 24 hours will be the second primary outcome. QR15 is a measurement of quality of recovery after surgery and anesthesia that has been psychometrically tested and validated. Reporting of outcome measures on a scale of 0 to 10 (0=None of the time and 10=All of the time). There are a total of 40 items/questions.

Time frame
24 hours postoperatively

Secondary outcomes

1

Mean opioid analgesic consumption

Postoperative cumulative oral morphine equivalent consumption during the first 24 hours

Time frame
24 hours postoperatively
2

Time to first analgesic request

Time frame
Up to 48 hours following surgery
3

Pain Assessment (VAS)

Visual Analogue Scale(VAS) - Pain:Overall pain assessed at rest and on movement A continuous scale comprised of a 100mm (10cm) horizontal line, anchored by 2 verbal descriptions No Pain to Worst Pain

Time frame
at 0, 6, 12, 18 and 24 hours
4

Risk of opioid-related side effects

nausea, vomiting, pruritus, sedation

Time frame
Up until one month following nerve block

Other outcomes

Locations

This trial has no locations.

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Women's College Hospital

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: