This study aims to test whether a multi-disciplinary intervention involving exercise and nutrition can slow down the decline in physical function, muscle strength and mass in older adults (aged 65 and above) with Type 2 diabetes (T2D) and obesity treated with Semaglutide.
The main questions it aims to answer are:
In older people with T2D and obesity, treated with Semaglutide, does a multi-disciplinary intervention of exercise and nutrition compared to standard health recommendations:
1. Reduce the rate of decline in muscle mass? 2. Reduce the rate of decline in muscle strength? 3. Reduce the rate of decline in physical function?
Participants will:
Administer Semaglutide once weekly for 6 months. Visit the clinic once every 8 weeks for checkups and tests. Keep a diary of their food consumption. Participants in the intervention group will participate in an online exercise program and will receive personal nutritional counseling.
Patients 65 years and above.
Patients who were previously diagnosed with type 2 diabetes.
Overweight / obesity (body mass index, BMI ≥ 27 kg/m2).
Patients with significant hearing or visual disability.
Patients with Estimated Glomerular Filtration Rate (eGFR)<30 ml/min/1.73 m2.
Patients who are in active nutritional therapy.
Patients who changed their diet recently (< 1 month) and/or in a weight-loss program with >5% weight loss or used anti-obesity drugs in the last 3 months.
Sheba Medical Center
Lead sponsor
Hadassah Medical Organization
Collaborator