Liver Biopsy in Diagnosis Neonatal Jaundice
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age1-1
SponsorAssiut University
About this trial
1. Identification and characterization of histopathological features of liver in cases of PNJ. 2. Assessment of key histological features in liver biopsy as diagnostic parameters in differentiating intra-hepatic and extra-hepatic causes of PNJ. 3. Evaluation of role of liver biopsy as a diagnostic tool in conjunction with clinical and laboratory findings.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
All cases presented with persistent neonatal jaundice in the first year of life in 5 years interval (2019-2023), received at Surgical Pathology Laboratory at Assiut University Hospitals, Egypt.
Disqualifiers
Patients older than one year.
Patients who underwent liver biopsy in the same age group but were not diagnosed as Persistent Neonatal Jaundice.
Patients with deficient clinical data.
Trial design
Design model
Single group
Treatments tested in this trial
Liver biopsy
Diagnostic testsurgical biopsy from liver
Treatment groups
50 Participants
are divided into 1 treatment groupGroup A: NeonatesExperimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
Identification of the key histopathological features in liver biopsy
Identification of the key histopathological features in liver biopsy that aid in differentiation intra-hepatic and extra-hepatic causes of persistent neonatal jaundice (PNJ).
Time frame
baselineSecondary outcomes
1
Evaluation of significance of liver biopsy as a diagnostic tool
Evaluation of significance of liver biopsy as a diagnostic tool with clinical and laboratory findings in detection of persistent neonatal jaundice (PNJ) causes.
Time frame
baselineLocations
Sponsors and contacts
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Source ClinicalTrials.gov
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