Health TrialsbyHealthPanel

Locating Biomarkers in OCD Through Behavioral Tasks

ConditionsOCDObsessive-Compulsive Disorder
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-65
SponsorBaylor College of Medicine

About this trial

Subjects that have a diagnosis of OCD will participate in a clinical interview and cognitive tasks, during which they will be exposed to their individual OC stressors or will be asked to make decisions related to information value and quantity while measuring neural activity and filming facial reactions. This will assist investigators to look for biomarkers of that change. This study offers a unique opportunity to develop biomarkers for key domains of OCD, and other neuropsychiatric disorders, that are grounded in brain neurocircuitry at the individual-patient level.

Subjects will participate in a clinical interview (Day 1), and then tasks+EEG (Day 2). Day 1 will be 4 hours or less, and Day 2 will be 2.5 hours or less.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Diagnosis of OCD

Non-pregnant if female

Minimum score of 16 on Y-BOCS

Ability to provide informed consent

Disqualifiers

Those not meeting inclusion criteria listed above

Lifetime diagnosis of psychotic disorders such as schizophrenia

Alcohol or substance abuse/dependence within 6 months, excluding nicotine

Deemed at high risk of suicidal behavior or impulsivity

Trial population

Potential subjects are patients diagnosed with OCD meeting the inclusion/exclusion criteria above.

Trial design

Design model

Case-only

Time perspective

Prospective

Treatments tested in this trial

  • Beads Task

    Behavioral

    Participants will be asked to make a series of decisions that involve combining information about the value and probability of potential rewards. Subjects will sit in front of a computer monitor and place their hand over a box with orange and blue button that they will be asked to press based on their idea of which one will be the majority in a jar full of orange and blue beads. This task should take 15-20 minutes to complete, not including EEG setup.

  • PROVOC Tasks

    Behavioral

    Three tasks will be developed collaboratively with the participant and independent evaluator that involve the participant being exposed to triggers that are considered by him/her impossible to confront without ritualizing. There will also be a similar process involving objects that should not cause any distress to be used as a control. Sessions will be videotaped with AFAR system concurrent to recording of LFPs from VS and scalp EEG.

Treatment groups

20 Participants
are divided into 1 treatment group
Group A: OCD group2 interventions

Trial outcomes

Primary outcomes

1

Investigate for biomarkers of obsessive compulsive disorder pathophysiology through the use of behavioral tasks - Beads task

Subject will perform beads task while EEG and videotape monitors neural and facial data throughout

Time frame
Day 2
2

Investigate for biomarkers of obsessive compulsive disorder pathophysiology through the use of behavioral tasks - PROVOC Task 1

Subject will undergo PROVOC Task 1 with Item 1 of 3 that may invoke OCD triggers while EEG and videotape monitors neural and facial data throughout

Time frame
Day 2
3

Investigate for biomarkers of obsessive compulsive disorder pathophysiology through the use of behavioral tasks - PROVOC Task 2

Subject will undergo PROVOC Task 2 with Item 2 of 3 that may invoke OCD triggers while EEG and videotape monitors neural and facial data throughout

Time frame
Day 2
4

Investigate for biomarkers of obsessive compulsive disorder pathophysiology through the use of behavioral tasks - PROVOC Task 3

Subject will undergo PROVOC Task 3 with Item 3 of 3 that may invoke OCD triggers while EEG and videotape monitors neural and facial data throughout

Time frame
Day 2

Secondary outcomes

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Baylor College of Medicine

Lead sponsor

Brown University

Collaborator

University of Pittsburgh

Collaborator

Butler Hospital

Collaborator

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: