Primary aim of the study is to assess the effect of 12-week daily avocado consumption on cerebral blood flow and markers of cardio- and vascular health in both, the periphery and the brain, in pre-diabetic individuals with overweight or obesity. Secondary objective is to assess the effects of 12-week daily avocado consumption on brain insulin sensitivity after intranasal insulin delivery, vascular function, markers of metabolic health, cognition, and psychological well-being. For that purpose a total of 34 men and women between the ages of 40-75 years old, will participate in a randomised crossover intervention study.
Men and women, aged between 40-75 years
Pre-diabetes: (A1C of 5.7%-6.4%, a fasting plasma glucose (FPG) of 100-125 mg/dL, or a 2-hour oral glucose tolerance test (OGTT) result of 140-199 mg/dL)
BMI ³ 25 kg/m2
Fasting serum total cholesterol < 8.0 mmol/L
Age less than 40 years old or older than 75 years
BMI < 25 kg/m2
Type 1 or type 2 diabetes
habitual consumption of more than 1 avocado/ week
Maastricht University Medical Center
Lead sponsor
Avocado Nutrition Center
Collaborator