The study will perform to follow-up UC-MSCs and CM transplantation. 18 patients will be called back to be examined after 5 years of UC-MSC and/or CM transplantation.
Visual field defects at the initial examination with Humphrey perimetry are between 25% to 50%
Willing to sign informed consent as research subjects
Willing to do the peribulbar injection with mesenchymal stem cells isolated from umbilical cord tissue
Willing to do visual field checks with Humphrey's perimetry, vision tests with Snellen boards, Optical Coherent Tomography (OCT) examinations, electroretinogram examinations and fill out a quality of life questionnaire
Pregnant or nursing women
Positive result of HIV test
Have a history of eye tumours
In the immunosuppressive treatment or other drugs that can affect the growth of transplanted stem cells
Retinitis Pigmentosa patients who have been transplanted UC-MSC and/or CM 5 years ago under clinical trials NCT04315025
Cohort
Retrospective
Conditioned Medium (CM)
Biological/VaccineConditioned Medium (CM) injected by peribulbar
Umbilical Cord Mesenchymal Stem Cell (UC-MSC)
Biological/VaccineUmbilical Cord Mesenchymal Stem Cell (UC-MSC) injected by peribulbar
Visual Acuity Test
a test to see the sharpness of vision using Snellen Chart which is read at a distance of 6 meters. Normal eye test results are stated in 6/6.
Visual Field Test
a test to assess the breadth of views of the lateral, medial, superior and inferior aspects using Humprey's perimetry.
Funduscopy
an examination to see and assess the abnormalities and conditions in the ocular fundus using an ophthalmoscope. This examination is carried out by an ophthalmologist.
Electrorectinography
an examination to provide a picture of objectivity, a quantitative measure of retinal function to monitor the function of stem cells and ganglion cells in the eye. This examination is carried out by a trained ophthalmologist.
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This trial is not recruiting at the moment. You can still explore other options:
