About this trial
Periodontal disease is an oral disease characterized by microbially associated, host-mediated inflammation of the periodontium. In the treatment of periodontal disease, conventional periodontal therapy includes both surgical and non-surgical approaches. Non-surgical therapy (i.e. scaling and root planing - SRP) remains an essential part of periodontal therapy. Here, diseased root surface debridement utilizing different hand and ultrasonic instrumentation is performed to facilitate periodontal re-attachment and to reduce the bacterial mass in the periodontal pocket.
In the last decade, the use of lasers (light amplification by stimulated emission of radiation) has occupied part of the dialogue within periodontology due to several proposed advantages. In the arena of periodontology, laser use, as an adjunct to non-surgical therapy, was demonstrated to enhance periodontal healing; however, it is still the matter of debate. Among laser applications, low-level laser therapy is recommended for its pain-reducing, woundhealing and anti-inflammatory effects.
Hyaluronic acid is a non-sulfated glycosaminoglycan and a major component of the extracellular matrix. It is found in various body fluids, such as gingival crevicular fluid, saliva, serum and synovial fluid. Anti-inflammatory, anti-edematous and anti-bacterial activities of hyaluronic acid have been investigated in dentistry, specially in periodontology.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
systemically healthy
nonsmokers
untreated periodontal disease (stage 3, grade B or C)
plaque index will not exceed 20%
Disqualifiers
systemic diseases with impact on periodontal health
medication with impact on periodontal health
smokers
pregnant and lactating women
Trial design
Parallel
Treatments tested in this trial
SRP+LASER (Dentsply Sirona - SIROLaser Blue)
Deviceadjunct irradiation with a diode laser (Dentsply Sirona - SIROLaser Blue) intrasulcularly to all sites with PD ≥ 4mm
SRP+HA
Deviceadjunct hyaluronic acid (Regedent, HyaDENT Cross linked hyaluronic intrasulcularly to all sites with PD ≥ 4mm
SRP
Devicenon-surgical periodontal therapy (SRP) with utrasonic device and curretes
Treatment groups
Trial outcomes
Primary outcomes
Probing pocket depth reduction
Change in probing pocket depth after treatment
Secondary outcomes
Clinical attachment level gain
Change in clinical attachment level after treatment
Bleeding on probing percentage reduction
Bleeding after measurement of pocket depth, reduction after treatment
Residual diseased site number
No of sites with PD ≥ 4mm and bleeding on probing after treatment
Sponsors and contacts
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University of Ljubljana
Lead sponsor
University Medical Centre Ljubljana
Collaborator