Lung and Heart Function Across Decades of Life in Health
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age24-68
SponsorUniversity of California, San Francisco
About this trial
The main objective of this study is to develop baseline "normal" reference values of both lung and heart function for healthy adults within the age range relevant to the United States Veteran population who served in the Southwest Asia theater of military operations.
This study will involve performing key components of the Department of Veterans Affairs the Airborne Hazards and Open Burn Pit Center of Excellence (AHOBPCE) and a VA network of Post-Deployment Cardiopulmonary Evaluation Network (PDCEN) Core Clinical Evaluation in asymptomatic unexposed healthy controls without known lung or heart disease to serve as a "normal" control comparator group for veterans evaluated by PDCEN.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Age 24-68
U.S. Veteran deployed between 1990 to 2021
No respiratory complaints (defined as modified Medical Research Council score = 0)
No use of respiratory medications
Disqualifiers
Non-English speaking
Pregnancy
BMI>35 Kg/m2
Tobacco smoking within prior year
Trial population
Healthy "normal" adults within the age range relevant to the United States Veteran population who served in the Southwest Asia theater of military operations.
Trial design
Design model
Cohort
Time perspective
Cross-sectional
Treatments tested in this trial
Healthy control
Other interventionObservational study with no intervention
Treatment groups
No treatment groups listed
Trial outcomes
Primary outcomes
1
Normal reference values for heart and lung function within the age range relevant to the United States Veteran population.
Pulmonary Function Testing: The purpose of this test is to determine the participant's lungs' capacity.
Time frame
2 years2
Normal reference values for heart and lung function within the age range relevant to the United States Veteran population.
Cardiopulmonary Exercise Testing: The purpose of this test is to determine the participant's lung and heart capacity during maximum exercise.
Time frame
2 years3
Normal reference values for heart and lung function within the age range relevant to the United States Veteran population.
Echocardiogram: The purpose of this test is to determine how well the subject's heart is functioning and identify causes of cardiac-related symptoms.
Time frame
2 yearsSecondary outcomes
1
Normal reference values for heart and lung function within the age range relevant to the United States Veteran population.
FeNO: The purpose of this test is to measure a marker of inflammation in the lungs.
Time frame
2 years2
Normal reference values for heart and lung function within the age range relevant to the United States Veteran population.
Forced Oscillation Technique: The purpose of this test is to determine the resistance of the airways in the subject's lungs.
Time frame
2 years3
Normal reference values for heart and lung function within the age range relevant to the United States Veteran population.
Methacholine Challenge Test: The purpose of this test is to determine how irritable the participant's airways are by administering gradually increasing doses of methacholine.
Time frame
2 years4
Normal reference values for heart and lung function within the age range relevant to the United States Veteran population.
Chest CT: The purpose of this test is to examine for abnormalities and to help diagnose the cause of signs or symptoms of chest disease.
Time frame
2 yearsSponsors and contacts
Click on the lead sponsor to view all of their trials.
University of California, San Francisco
Lead sponsor
US Department of Veterans Affairs
Collaborator
Source ClinicalTrials.gov