Health TrialsbyHealthPanel

Lung Recruitment and PEEP Effects on Intracranial Pressure in Cranial Surgery

ConditionsIntracranial Pressure IncreaseMechanical Ventilation Complication
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-75
SponsorUniversity of Chile

About this trial

High positive end-expiratory pressure (PEEP) levels required to achieve clinical benefits may increase ICP and reduce cerebral perfusion pressure (CPP) in patients at risk of intracranial hypertension.

However, individualizing ventilation parameters is essential for each patient. Among protective ventilation strategies, PEEP is key to preventing alveolar collapse. The PEEP level that minimizes alveolar collapse while avoiding overdistension of the pulmonary parenchyma is known as the Best PEEP. This study aims to evaluate the application of Best PEEP in cranial neurosurgery.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

ASA classification I-III.

Elective cranial neurosurgery.

Disqualifiers

ASA classification IV or higher.

Documented intracranial hypertension.

Severe pulmonary disease (e.g., asthma, COPD).

Emergency surgery.

Trial population

Patients with intracranial disease undergoing elective intracranial surgery

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

  • Subdural pressure measurement

    Procedure/Surgery

    Subdural intracranial pressure (SDIP) will observed during an alveolar recruitment maneuver and best PEEP titatration. SDIP will be measured while mechanical ventilation is maintained using the identified best PEEP.

Treatment groups

No treatment groups listed

Trial outcomes

Primary outcomes

1

Subdural intracranial pressure (sICP) mmHg

Change in sICP during an alveolar recruitment maneuver (ARM)

Time frame
during the procedure

Secondary outcomes

1

Pulmonary mechanics parameters

To describe pulmonary mechanics parameters, including plateau pressure (cmH2O) and driving pressure.(cmH2O)

Time frame
Intraoperative

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University of Chile

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: