Machine Learning-based Longitudinal Study of Post-ICU Syndrome Development Trajectory in Critically Ill Patients and Construction of Clinical Early Warning Models: a Research Protocol for Longitudinal Study

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-100
SponsorThe Affiliated Hospital Of Guizhou Medical University

About this trial

This project intends to track and evaluate whether post-ICU syndrome will occur 7 days, 1 month, 3 months and 6 months after ICU patients are transferred out of the ICU through a longitudinal study, apply the latent category growth model to identify different trajectory patterns of post-ICU syndrome in critically ill patients, and use modern machine learning models to build an early warning model of the trajectory patterns of post-ICU syndrome.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

Length of stay in ICU ≥24h;

Age ≥18 years old;

Conscious when leaving ICU, communicating with investigators without barriers;

Informed consent. Family members:

Disqualifiers

Have been in ICU for more than 24h within 3 months before this admission;

Transferred to another ICU;

Cognitive impairment existed before ICU admission (BDRS > 4 points);

Severe hearing impairment, dysarthria, etc., which cannot be followed up;

Trial population

Stage one involved studying patients discharged from the ICU and their families to investigate the occurrence and factors influencing post-intensive care syndrome (PICS), identifying various developmental patterns of PICS. A minimum sample size of 840 patients and 420 family members was established. Stage two focused on developing and evaluating a machine learning-based early warning model for PICS. The model construction utilized data from stage one, while the evaluation included 525 patients and 393 family members who met the exclusion criteria.

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

Not listed

Trial groups

No trial groups listed

Trial outcomes

Primary outcomes

1

Correlation scale score

Patient: 1. Post-icu syndrome assessment of ICU survivors: Healthy Aging Brain Care monitoring(HABC Monitor) score; 2. ICU related Memory: Intensive Care Unit Memory Tool (ICUMT); 3. Sleep quality: Richards-Campbell Sleep Questionnaire (RCSQ); 4. Perceived Social Support Scale (PSSS). Family members: 1. Sleep quality of family members: Richards-Campbell Sleep Questionnaire (RCSQ); 2. anxiety and Depression of family members: Hospital anxiety and Depression Scale score; 3. Family fatigue: Scores of fatigue rating Scale; 4. PTSD of family members: Event Impact Scale score;

Time frame
2024-2026

Secondary outcomes

Other outcomes

Sponsors and contacts

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