Machine Learning in Quantitative Stress Echocardiography

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age20-89
SponsorHull University Teaching Hospitals NHS Trust

About this trial

Greater diagnostic accuracy is required to find out who is at risk of a heart attack as this can reduce the requirement of more invasive downstream tests and thereby improve the patient experience and also reduce their exposure to risk. Stress echocardiography is a routine clinical test that involves using ultrasound to image the heart whilst it is under stress to assess the risk of a heart attack.

This study will focus on developing more accurate analysis tools to interpret the results of these stress echocardiographic scans. New methods will be tested to measure the function of each part of the heart muscle, using advanced analysis of the information obtained when high-frequency sound waves are bounced off the heart inside the chest. The researchers will measure and report exact heart function during stress, so that they will be able to recognise normal hearts and those with any disease. New computer methods will be developed to display any abnormality, which will make it easier for doctors to choose the best treatment for patients who are at risk.

The goals and potential benefits of this research proposal are to update the interpretation of a routinely used clinical test (stress echocardiography) to produce a reliable new method for diagnosing the precise effects of diseased arteries on the function of the heart muscle; to develop new computer graphics that adapt to show individual risks for each patient; and to implement new computer models that can be constantly updated

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Clinically suitable for stress echocardiography examination

Disqualifiers

None

Trial population

All patients will be recruited into this study as a single group, with an age range of 20 - 89 years and with no restriction according to their pre-test probabilities of coronary artery disease. They will be eligible for inclusion so long as they have chest pain or another clinical indication for stress testing.

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

  • Analysis

    Other intervention

    No intervention planned. Novel analysis of echocardiographic data.

Treatment groups

1,250 Participants
are divided into 1 treatment group
Group A: Chest pain1 intervention

Trial outcomes

Primary outcomes

1

Inducible myocardial ischaemia

Diagnostic performance of the machine learning classifier for the detection of inducible myocardial ischaemia as determined by reduced coronary flow reserve

Time frame
3 years

Secondary outcomes

1

Workload

Diagnostic performance of workload (units = watts) for the detection of inducible myocardial ischaemia as determined by reduced coronary flow reserve.

Time frame
3 years
2

Velocity

Diagnostic performance of velocity (units = m/s) for the detection of myocardial functional reserve compared with quantitative coronary arteriography and with coronary flow reserve.

Time frame
3 years
3

Strain rate

Diagnostic performance of strain rate (units = s\^-1) for the detection of myocardial functional reserve compared with quantitative coronary arteriography and with coronary flow reserve.

Time frame
3 years
4

Strain

Diagnostic performance of strain (units = s) for the detection of myocardial functional reserve compared with quantitative coronary arteriography and with coronary flow reserve.

Time frame
3 years

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Hull University Teaching Hospitals NHS Trust

Lead sponsor

Barts & The London NHS Trust

Collaborator

Cardiff and Vale University Health Board

Collaborator