Machine Learning Model Based on Baroreflex Sensitivity for Predicting Post-Induction Hypotension in Elderly Patients

Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age65+
SponsorPeking Union Medical College Hospital

About this trial

The purpose of this study is to develop a high-performance machine learning model combining dynamic baroreflex sensitivity (BRS) metrics and multi-dimensional static clinical features to predict the risk of post-induction hypotension (PIH) in elderly patients undergoing elective non-cardiac surgery under general anesthesia.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Aged over 65 years;

Scheduled for elective non-cardiac surgery;

American Society of Anesthesiologists (ASA) physical status classification I-III;

Planned for general anesthesia with endotracheal intubation;

Disqualifiers

Severe peripheral vascular diseases;

Secondary hypertension;

Presence of physical tremors (e.g., Parkinson's disease) preventing stable recording;

Inability to accurately measure upper limb blood pressure;

Trial population

Patients scheduled for elective operations

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

Not listed

Trial groups

500 Participants
are grouped into 1 trial group
Group A: Elderly Surgical Patients

Trial outcomes

Primary outcomes

1

Incidence of Post-Induction Hypotension (PIH)

Defined as a systolic blood pressure (SBP) \<90 mmHg , a mean arterial pressure (MAP) \<65 mmHg, or a decrease in MAP exceeding 30% from baseline measurements.

Time frame
From immediately after anesthesia induction up to 20 minutes post-induction or before surgical incision.

Secondary outcomes

1

1. Early Intraoperative Hypotension Rate

Defined as a systolic blood pressure (SBP) \<90 mmHg , a mean arterial pressure (MAP) \<65 mmHg, or a decrease in MAP exceeding 30% from baseline measurements.

Time frame
From surgical incision to the end of the operation.
2

Postoperative Complication

Time frame
Up to 30 days post-surgery

Other outcomes

Sponsors and contacts

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