Macular Resurfacing Using Autologous ILM Patch Transposition for Idiopathic Epiretinal Membrane

Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorXinhua Hospital, Shanghai Jiao Tong University School of Medicine

About this trial

Idiopathic epiretinal membrane is a condition in which abnormal tissue grows on the surface of the retina and can cause blurred vision and distortion. The standard surgical treatment is removal of this membrane, but some patients may not achieve complete visual recovery because the normal structure of the central retina may not fully restore after surgery.

This study is a prospective randomized controlled trial designed to evaluate a new surgical technique called macular resurfacing using an autologous internal limiting membrane patch transposition. The technique uses a patient's own retinal tissue to cover the macular area after epiretinal membrane removal, with the aim of promoting more natural healing of the retinal surface.

Patients with idiopathic epiretinal membrane will be randomly assigned to receive either the new surgical technique or conventional epiretinal membrane peeling. Visual function and retinal structural changes will be evaluated using visual examinations and multimodal retinal imaging during follow-up. The study aims to determine whether this new technique can improve visual outcomes and promote better restoration of macular microstructure.

Eligibility criteria

Qualifiers

Diagnosis of epiretinal membrane confirmed by Spectral-domain Optical Coherence Tomography

Best corrected visual acuity <= 0.8 (equivalent to 0.1 LogMAR)

Presence of metamorphopsia confirmed by Amsler grid testing

Ability to understand the study information and provide written informed consent voluntarily

Disqualifiers

History of intraocular surgery, with the exception of uncomplicated cataract surgery

Presence of any of the following ocular diseases: retinal vascular diseases (including diabetic retinopathy, retinal hemangioma, retinal vascular occlusion, Coats' disease, etc.), uveitis, macular degeneration, macular hole, retinal detachment, retinoschisis, pathologic myopia, ocular trauma, intraocular tumor and neurofibromatosis.

Trial design

Treatments tested in this trial

  • Non-Inverted Autologous Internal Limiting Membrane (ILM) Patch Transposition
  • Conventional Epiretinal Membrane and Internal Limiting Membrane Peeling

Treatment groups

90 Participants
are divided into 2 treatment groups

Locations

This trial has no locations