Magnesium Sulfate for Prevention of Emergence Agitation in Lumbar Disc Surgery
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-70
SponsorOndokuz Mayıs University
About this trial
In this retrospective study, the effect of intraoperative magnesium sulfate infusion on the incidence of postoperative emergence agitation was evaluated in adult patients who underwent elective lumbar microdiscectomy under general anesthesia. The medical records of patients aged 18-70 years with an ASA physical status of I-II were retrospectively reviewed. Patients were evaluated according to whether they received intraoperative magnesium sulfate infusion as part of anesthetic management. The primary outcome measure was the incidence of emergence agitation in the post-anesthesia care unit; this assessment was based on Ramsay Sedation Scale scores recorded in the post-anesthesia care unit at admission and at 5, 10, 15, and 30 minutes. Secondary outcome measures included postoperative pain scores assessed using the Numeric Rating Scale, intraoperative remifentanil consumption, recovery and extubation times, tramadol requirement in the post-anesthesia care unit, and possible adverse events related to magnesium infusion.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
None
Disqualifiers
None
Trial population
Adult patients aged 18-70 years with an ASA physical status of I or II who underwent elective single-level lumbar microdiscectomy under general anesthesia at Giresun Training and Research Hospital were included in the study population. The study population consisted of patients whose medical records contained complete perioperative and post-anesthesia care unit data required for the retrospective evaluation of intraoperative magnesium sulfate infusion and postoperative emergence agitation.
Trial design
Design model
Cohort
Time perspective
Other
Treatments tested in this trial
Magnesium Sulfate Infusion
DrugMagnesium Sulfate (Experimental Group) Intravenous bolus of magnesium sulfate 30 mg/kg administered over 15 minutes immediately after induction of general anesthesia, followed by continuous infusion at 10 mg/kg/h until the end of surgery. Solutions were prepared in identical syringes and infusion bags by an anesthesia technician not involved in patient care. The preparation and administration protocol ensured blinding of participants, anesthesia providers, and outcome assessors.
0.9% Saline Infusion
Drugntravenous bolus and continuous infusion of 0.9% sodium chloride solution in the same volume, infusion rate, and duration as the magnesium sulfate group. Solutions were indistinguishable in appearance and prepared under the same blinding procedures.
Treatment groups
70 Participants
are divided into 2 treatment groupsGroup A: Magnesium Sulfate Infusion1 intervention
Group B: 0.9% Saline Infusion1 intervention
Trial outcomes
Primary outcomes
1
Incidence of Emergence Agitation in the PACU
Percentage of participants with a Ramsay Sedation Scale (RSS) score ≥5, indicating emergence agitation, in the post-anesthesia care unit (PACU)
Time frame
At PACU admission (T0) and at 5, 10, 15, and 30 minutes post-admission.Secondary outcomes
1
Postoperative Pain Scores in PACU
Numeric Rating Scale (NRS) pain scores ranging from 0 (no pain) to 10 (worst pain).
Time frame
At PACU admission (T0) and at 5, 10, 15, and 30 minutes post-admission.Locations
Sponsors and contacts
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Source ClinicalTrials.gov
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