Pakistan, being a developing country, is one of the regions with the most cases of organophosphate (OP) poisoning/toxicity. MgSO4 is one of the most promising adjunctive treatments that needs to be tested. This study is being carried out with the objective of comparing the 15-day all-cause mortality rate and the total cumulative atropine requirement during hospitalization between patients receiving adjunctive magnesium sulphate with standard therapy and those receiving standard therapy alone.
Both genders
Adult patients aged between 18 and 50 years
Confirmed clinical diagnosis of organophosphate poisoning containing insecticide, through the oral route
Adult patients, or their legally authorized representative, who will provide informed consent to participate in the study
Patients with known allergy to MgSO4
Patients with documented pre-existing renal impairment (Serum creatinine more than 1.5mg/dl)
Patients with documented pre-existing cardiac impairments (e.g., heart block)
Pregnant or lactating women
Muhammad Aamir Latif
Lead sponsor
RESnTEC, Institute of Research
Sponsor institution