Magnetic Resonance Elastography in Glioma: Exploring Tumor Stiffness and Adhesion
ConditionGlioma
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-80
SponsorShengjing Hospital
About this trial
this study will investigate the relationship between tumor stiffness and adhesion in gliomas using MRE. By utilizing preoperative MRE and Intraoperative neuronavigation, followed by comprehensive molecular pathology analysis, we aim to explore the correlation of tumor stiffness and adhesion with molecular and genetic characteristics of gliomas. Additionally, the predictive value of MRE in terms of pathological staging and prognosis will be determined. This research may pave the way for improved clinical decision-making, personalized treatment approaches, and more accurate clinical trials for glioma patients.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
age older than 18 years
Karnofsky performance status higher than 60
with written informed consent
MRE performed within one week before surgery
Disqualifiers
previous treatment for glioma
inability to complete MRE due to intolerance (e.g., vibration-related discomfort or claustrophobia)
completed MRE with suboptimal wave image quality (e.g., motion artifacts or inad-equate wave amplitude)
failure to proceed with surgery after MRE
Trial design
Design model
Single group
Treatments tested in this trial
Magnetic Resonance Elastography
Diagnostic testUndergo MRE and routine MRI
Assessment and Recording
Procedure/SurgeryUndergo recording of tumor stiffness during surgery and molecular pathological classification through genetic analysis
Treatment groups
100 Participants
are divided into 1 treatment groupGroup A: Diagnostic (MRE, tumor grade, tumor stiffness and adhesion)Experimental treatment 2 interventions
Trial outcomes
Primary outcomes
1
Surgical assessment of tumor stiffness
The surgeon will score the tumor stiffness in seven aspects, ranging from 1 to 5 points: Tumor size; Shape of tumor; Tumor texture; Stiffness of the tumor's capsule; Stiffness of the tumor's central region; Primary methods of tumor removal; Features of tumor's capsule.
Time frame
Baseline to 6 weeks2
Surgical assessment of tumor adhesion
The surgeon will score the tumor's adhesion based on seven aspects, ranging from 1 to 4 points: Stripping instruments; Frequency of use of sharp instruments; Adhesion range; Degree of tumor resection; Cranial nerve anatomy preservation; Brain tissue anatomy preservation; Neurological function (compared with preoperative).
Time frame
Baseline to 6 weeks3
Radiological assessment of tumor stiffness
Tumor stiffness, measured in kilopascals (kPa), will be compared with its normal-appearing contralateral white matter using MRE by creating a lesion region of interest (ROI). Images were acquired on a 3T MR imaging unit with a vibration frequency of 60 Hz. The performance of the use of tumor stiffness to predict tumor grade was evaluated with the Wilcoxon rank sum, 1-way ANOVA, and Tukey-Kramer tests.
Time frame
MRE performed within one week before surgerySponsors and contacts
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Source ClinicalTrials.gov