Magnetic Resonance Imaging Assessment of Multiorgan Health in Obesity
ConditionChildhood Obesity
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age12-18
SponsorAlder Hey Children's NHS Foundation Trust
About this trial
The goal of this study is to quantify the body composition and organ fat distribution changes with obesity interventions in adolescents with severe obesity. The main question the investigators aim to answer is if there is improvement in organ health with weight loss intervention. The investigators will be comparing the degree of these changes between children being treated with GLP1 receptor agonists in addition to lifestyle changes and those managed with lifestyle changes alone. Participants will undergo MRI body composition at baseline and after 9 months.
Eligibility criteria
Qualifiers
Age 12 to <18 years at the time of enrolment
BMI >99.6th centile or >2.67 SDS
Informed consent from parent(s) (or person with parental responsibility) and assent from the child or young person for participants aged less than 16 years (or)
Informed consent from the participant if aged ≥ 16 years.
Disqualifiers
Body weight above upper limit of the scanner (>250 kilograms)
Needs general anaesthesia for the MRI scanning
Any contraindications for MRI- Metal implants/claustrophobia
Previous use of GLP-1 receptor agonist
Trial design
Treatments tested in this trial
- Not listed
Trial groups
30 Participants
are grouped into 2 trial groupsSponsors and collaborators
Source ClinicalTrials.gov