This proposal seeks to carry out a prospective, single-arm open label study aimed at sustaining treatment-resistant depression (TRD) response in patients with TRD who had responded to prior individualized resting-state functional connectivity (rs-FC)-guided intermittent theta burst stimulation (iTBS). It also seeks to detect and predict relapse risk by integrating rs-FC iTBS with a TMS-adapted needs-based symptom-titrated algorithm based longitudinal ECT (STABLE) maintenance scheduling algorithm, and passive digital biomarkers.
Male/ female aged ≥ 21 to ≤ 70 years old
Able to give informed consent
Able to understand English
DSM-V diagnosis of current/ past major depressive disorder (MDD) episode
DSM-5 psychotic disorder
Drug or alcohol abuse or dependence (preceding 3 months)
Significant neurological disorder, which may pose increased risks with TMS, e.g., epilepsy
Metal in the cranium, skull defects, pacemaker, cochlear implant, medication infusion pump or any other electronic implants or devices
National University Hospital, Singapore
Lead sponsor
National University of Singapore
Collaborator