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Management of Post-operative Respiratory Failure by Using NIV and High Velocity Nasal Insufflation (HVNI)

ConditionsRespiratory Failure Without HypercapniaRespiratory Failure With HypercapniaPostoperative Respiratory Complication
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorAssiut University

About this trial

Postoperative respiratory failure (PORF) remains a critical driver of morbidity, mortality, and incremental care costs in surgical populations. Traditional escalation often involves invasive mechanical ventilation, which is associated with ventilator-associated pneumonia (VAP), prolonged intensive care unit (ICU) stays, and increased resource burden.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Age above 18 years

within 48 hours after major surgery

PAO2/FIO2 less than 200

Signs of respiratory distress and respiratory rate (RR) more than 25 cycles/minute

Disqualifiers

Age below 18 years

Pregnant ladies

Orofacial trauma or burns

Active Gastrointestinal bleeding

Trial design

Design model

Parallel

Treatments tested in this trial

  • BIPAP

    Device

    The second arm (NIV group) will be managed by BIPAP device for post-operative respiratory failure

  • Vapotherm

    Device

    The first arm (HVNC group) will be managed by Vapotherm device for post-operative respiratory failure

Treatment groups

180 Participants
are divided into 2 treatment groups
Group A: Non-invasive Ventilation groupExperimental treatment 1 intervention
Group B: High Velocity Nasal Cannula (HVNC) groupExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Weaning success

The primary outcome will be comparing the weaning success (in days) for both arms of the study group. This will be accessed after 48 hours and on a daily basis until the weaning criteria are met or for 28 days.

Time frame
At 48 hours and then daily for 28 days.

Secondary outcomes

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Assiut University

Lead sponsor

Source ClinicalTrials.gov
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