Health TrialsbyHealthPanel

Mapping Epileptic Networks Using Multimodal Imaging

ConditionEpilepsy in Children
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
AgeUp to 18
SponsorImagine Institute

About this trial

Currently, mapping the epileptogenic zone is based on a comprehensive preoperative assessment involving clinical, imaging and electrophysiological examinations.

To reduce the need for invasive stereoelectroencephalography (SEEG) explorations, electrophysiological and imaging methods have been developed, such as resting-state functional MRI (fMRI) coupled with electroencephalogram and arterial spin-labeling perfusion MRI (ASL-MRI).

It has been published that these new methods enable precise delineation of the epileptogenic zone and better preparation for surgery.

The aim is to determine whether, in children with focal lesional epilepsy, the combination of ASL-MRI-EEG and resting-state fMRI-EEG enables precise identification of the epileptogenic zone to be defined by SEEG, the current reference examination.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Be under 18 years of age on the day of inclusion.

refractory focal lesional epilepsy

rare non-lesional epilepsy

Present abnormalities (spikes) on the intercritical EEG

Disqualifiers

Requiring general anesthesia for MRI

Require sedation specifically for research

Have generalized epilepsy

Be deprived of liberty or under guardianship.

Trial population

Children with refractory focal epilepsy, possibly due to lesions

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

  • Secondary data collection

    Other intervention

    clinical data

Treatment groups

75 Participants
are divided into 1 treatment group
Group A: Patients1 intervention

Trial outcomes

Primary outcomes

1

Determine whether, in children with lesional focal epilepsy, the combination of ASL-MRI-EEG and resting-state fMRI-EEG can accurately identify the epileptogenic zone to be defined by SEEG, today's gold standard.

Time frame
15 years

Secondary outcomes

1

Study the pathophysiology of resistant lesional epilepsies

Measurements of perfusion in ASL-MRI (inter and/or percritical) and the BOLD effect in resting-state fMRI

Time frame
15 years
2

Correlate cortical perfusion change on SL-ASMRI and BOLD signal abnormalities on resting-state fMRI

Time frame
15 years
3

Compare cortical perfusion abnormalities and resting-state fMRI based on EEG data in MRI.

Time frame
15 years
4

Correlate BOLD-MRI perfusion abnormalities with anatomical (DTI (tractography)) and functional (resting-state fMRI) brain connectivity abnormalities.

Time frame
15 years

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Imagine Institute

Lead sponsor

Source ClinicalTrials.gov
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