This proposal seeks to carry out a double-blinded, randomized, comparative study that investigates neurobehavioral changes induced by personalized, anxiosomatic and dysphoric network guided accelerated intermittent-theta burst (iTBS) using dense functional Magnetic Resonance Imaging (fMRI) sampling in participants with treatment-resistant depression (TRD) and moderate/high levels of anxiety.
Male/female aged 21-70
Diagnosis of MDD as validated by MINI
Non-response to adequate trial (4 weeks) of at least two MDD medication as verified by the study clinician
BDI score of 20 or above; BAI score of 16 or above
DSM-5 psychotic disorder
Drug or alcohol abuse or dependence (preceding 3 months)
Rapid clinical response required, e.g., high suicide risk
Significant neurological disorder, which may pose increased risks with TMS, e.g., epilepsy
National University Hospital, Singapore
Lead sponsor
National University of Singapore
Collaborator