Matching Treatments to Cognitive Deficits in Offenders With Substance Use Disorders
ConditionAntisocial Behavior
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexMale
Age18-55
SponsorThe Mind Research Network
About this trial
The goal of this clinical trial is to investigate the effect of two types of cognitive remediation training on real-world behavioral outcomes including substance use, institutional adjustment, and recidivism following release from prison. Each training type is designed to target one of two subtypes of antisocial criminal offenders, who are characterized by either: 1) Attention to context-based deficits, or 2) Affective cognitive control-based deficits.
The main questions it aims to answer are:
Does matching deficit type with targeted cognitive training improve outcomes (relative to mismatched training)? What are the functional brain mechanisms that underlie treatment change?
Participants will:
Be assigned to cognitive training that either does or does not match their deficit type.
Complete six one-hour sessions of cognitive skills training. Complete pre and post-training behavioral tasks assessing self-regulation deficits.
Complete structural MRI scans and functional MRI scans assessing cognitive control.
Complete post-treatment follow-up assessments evaluating self-regulation, adjustment, and stressful life events, substance use and recidivism.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Currently incarcerated
No uncorrectable auditory or visual deficits
Able to speak and/or understand English
5th grade reading level or higher
Disqualifiers
None
Trial design
Design model
Parallel
Treatments tested in this trial
Attention to Context (ATC) training
BehavioralATC training focuses on learning to attend to and integrate contextual cues present in the environment. Three tasks, Reversal Learning, Divided Visual Field, and Affective Gaze, require ATC functioning and provide individuals with practice noticing changes in contextual information, such as rule changes and using emotion information to modulate behavior.
Affective Cognitive Control (ACC) training
BehavioralACC training focuses on providing individuals with practice inhibiting behavior, particularly within motivational or affective contexts. Three tasks, Shapes, Numbers, and Lottery, tap ACC functioning and place demands on the basic employment of cognitive control, such as task switching, as well as on the concurrent engagement of cognitive control and affective processing.
Treatment groups
288 Participants
are divided into 3 treatment groupsGroup A: Attention to context deficitExperimental treatment 2 interventions
Group B: Affective Cognitive Control deficitExperimental treatment 2 interventions
Group C: No psychopathologyExperimental treatment 2 interventions
Trial outcomes
Primary outcomes
1
Cognitive task performance - Stroop
Stroop task. Performance is quantified by number of correct responses (0 - 100)%.
Time frame
From enrollment to end of treatment at six weeks2
Cognitive task performance - Lexical Decision Making
Lexical Decision Making task. Performance is quantified by number of correct responses (0 - 100%).
Time frame
From enrollment to end of treatment at six weeks3
Cognitive task performance - Delay Discounting
Delay Discounting task. Performance is quantified quantified by calculating where the answers place the respondent amid reference discounting curves. Range 0.0-0.5.
Time frame
From enrollment to end of treatment at six weeks4
Functional MRI - Go/NoGo task performance
Functional MRI task performance (Go/NoGo task). Performance is quantified by the number of 'false alarms' (responding to the NoGo stimulus). Range 0-39.
Time frame
Change assessed from enrollment to end of treatment at six weeksSponsors and contacts
Click on the lead sponsor to view all of their trials.
The Mind Research Network
Lead sponsor
National Institute on Drug Abuse (NIDA)
Collaborator
Source ClinicalTrials.gov