The MGBIG is a study exploring cross-generational effects in 5000 women and their children and grandchildren located in Guangzhou, China. Its initial aim is to facilitate research on understanding the interplay between genes and environmental factors on disease etiology and on explaining the cause of the disease from the perspective of "grandmother-mother-child" heredity. Data are collected regarding environmental exposures, lifestyle, and social support on grandmother from birth to old age. Biological samples including blood and tissue samples are collected.
Maternal Grandmother' grandchildren delivered in Guangzhou Women and Children's Medical Center
Baseline information of maternal grandmother's daughter during pregnancy available
Significant cardiovascular abnormalities
Intelligent obstacle, intellectual disabilities or gawkish condition
All maternal grandmothers of the children in the Born in Guangzhou Cohort Study (BIGCS) would be recruited.
Cohort
Retrospective
Haplotypes transfered by non-inherited maternal antigens from maternal grandmother to female offspring
Assessed by analyses of MHC haplotypes, HLA haplotypes, and levels of non-inherited maternal antigens of mother and offspring, and pregnancy complication of maternal grandmothers and mothers
Serum levels of Inflammatory factors at grandchildren's birth and early neonatal life
Assessed by analyses of IL-1, IL-6, IL-10, IL-12, etc.
The prevalence of eczema of grandchildren
Assessed by self-reported time of onset and electronic medical record
The incidence of asthma of grandchildren
Assessed by self-reported time of onset and electronic medical record
The prevalence of Allergic rhinitis of grandchildren
Assessed by self-reported time of onset and electronic medical record
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Guangzhou Women and Children's Medical Center
Lead sponsor
Children's Hospital Medical Center, Cincinnati
Collaborator
University of Birmingham
Collaborator
