About this trial
The purpose of this study is to develop a pilot screening protocol, comparing cardiac point-of-care ultrasound (POCUS), electrocardiogram (EKG), serum biomarkers (N-terminal pro b-type natriuretic peptide (NT-proBNP), high sensitivity troponin (hsTn)) with formal transthoracic echocardiogram (TTE) in pregnant women with methamphetamine use.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
18 years or older > 20 weeks gestation admitted to the hospital
Active patient-defined regular methamphetamine use for at least 1 year and any use within the last month
Able to understand and provide informed consent
Able to understand English
Disqualifiers
Prescribed stimulants
Echocardiogram or EKG previously performed during current pregnancy
Previous diagnosis of congestive heart dysfunction
Previous diagnosis of pulmonary hypertension
Trial population
Pregnant women \> or equal to 20 weeks gestation presenting to OHSU for hospital, day patient, or observation admission will be identified via the electronic medical record.
Trial design
Case-only
Prospective
Treatments tested in this trial
Not listed
Trial groups
Trial outcomes
Primary outcomes
Sensitivity of point of care cardiac ultrasound for the detection of left ventricular systolic dysfunction as compared to comprehensive transthoracic echocardiogram.
This outcome seeks to identify the sensitivity of point of care cardiac ultrasound for the identification of left ventricular systolic dysfunction in pregnant people who use methamphetamine when performed by an obstetrics provider, as compared to formal transthoracic echocardiogram.
Secondary outcomes
Sensitivity of cardiac biomarkers and ECG for the identification of left ventricular systolic dysfunction as compared to comprehensive transthoracic echocardiogram. methamphetamine
This outcome seeks to identify the sensitivity of N-terminal pro-B-type natriuretic peptide (NT-proBNP), high sensitivity troponin and electrocardiogram for the identification of left ventricular systolic dysfunction in pregnant people who use methamphetamine, as compared to formal transthoracic echocardiogram.
Prevalence of underlying structural heart disease in pregnant people who use methamphetamine
This outcome seeks to identify the prevalence of structural heart disease in pregnant people who use methamphetamine.
Pregnancy and delivery outcomes in people who use methamphetamine
This outcome seeks to identify the prevalence of pregnancy delivery complications in people who use methamphetamine.
Changes to pregnancy-related treatment plan based on cardiovascular screening in people who use methamphetamine.
This outcome seeks to identify linkage to cardiovascular and addiction specialty care among patients diagnosed with cardiovascular disease.
Locations
Sponsors and contacts
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