MCI Speech in Noise
ConditionMild Cognitive Impairment
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age55-80
SponsorDartmouth-Hitchcock Medical Center
About this trial
The purpose of this study is to determine whether people with MCI (Mild Cognitive Impairment) and healthy comparison subjects differ with respect to their ability to hear soft sounds and how their brain understands and processes sound. The investigators are also evaluating, within those with MCI, whether the hearing tests are associated with neurocognitive functioning. The investigators are interested in learning whether changes in cognition in those with MCI can be detected using tests of how the brain processes sound. The investigators hypothesize that participants with MCI will score worse on both hearing tests and neurocognitive tests than participants without MCI. Participants are asked to complete multiple types of hearing tests, take a series of neurocognitive tests, and complete a few questionnaires.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Adults diagnosed with or suspected to have MCI (for MCI group) or are cognitively normal (for Control group)
Absence of other risk factors that might affect CAP (Central Auditory Processing) performance (e.g., active ear infections, congenital developmental delay, severe hearing loss)
Age 55-80
Normal hearing sensitivity (<40 dB HL Pure Tone Average (average of 500, 1000, 2000 Hz) thresholds bilaterally
Disqualifiers
Active ear infections or abnormal middle ear pathology
Other health condition prohibiting the completion of the CAP test battery
Mild to profound peripheral hearing loss (>40 dB (decibel) HL (hearing loss) Pure Tone Average (average of 500, 1000, 2000 Hz) bilaterally
Adults unable to consent
Trial population
The community in and around Lebanon, NH and patients from DHMC.
Trial design
Design model
Case-control
Time perspective
Cross-sectional
Treatments tested in this trial
Not listed
Trial groups
70 Participants
are grouped into 2 trial groupsGroup A: MCI
Group B: Control
Trial outcomes
Primary outcomes
1
Hearing-in-Noise Test Performance
The performance for Hearing in Noise Tests (HINT) between energetic masking and 2-talker informational masking (IM). Performance will be measured by the lowest signal-to-noise ratio (volume at which sentences are presented compared to background noise volume) that can be heard by the participant.
Time frame
1 time point (takes 15 minutes)2
Triple Digit in Noise Test Performance
Performance for the behavioral Triple Digit (TDT) between energetic masking and 2-talker informational masking (IM). Performance will be measured by the lowest signal-to-noise ratio (volume at which digits are presented compared to background noise volume) that can be heard by the participant.
Time frame
1 time point (takes 15 minutes)3
Size of auditory neural response in background noise
The change in amplitude of neural response between energetic masking and 2-talker informational masking (IM).
Time frame
1 time point (takes 45 minutes)4
Timing of auditory neural response in background noise
The change in latency of neural response between energetic masking and 2-talker informational masking (IM).
Time frame
1 time point (takes 45 minutes)Sponsors and contacts
Click on the lead sponsor to view all of their trials.
Dartmouth-Hitchcock Medical Center
Lead sponsor
Dartmouth College
Collaborator
Source ClinicalTrials.gov