Health TrialsbyHealthPanel

Measurement of Acute Metabolite Changes Following Consumption of Microalgae Drinks

ConditionsProtein Absorption and Amino Acid AvailabilityMetabolomics
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age21-60
SponsorNational University of Singapore

About this trial

Protein consumption is essential for various physiological processes, with microalgae and plant proteins gaining increasing attention due to their health benefits. To better understand how different protein types and processing methods impact health outcomes, this study aims to analyse the metabolite changes in response to different protein sources.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

English-literate and able to give informed consent

Singaporean Chinese Adults aged 21 to 60 (inclusive)

Body mass index of 18.5 to 23.0 kg/m² (inclusive)

Healthy (Based on results from screening session)

Disqualifiers

Currently participating in another clinical study that involves altering the regular diet and/or involves consuming a dietary supplement or investigated food product as an intervention

High blood pressure (≥ 140/90 mmHg)

Underlying health conditions that may affect metabolic functions

Consuming amino acid or protein supplements, or protein drinks, regularly (i.e., more than three times a week) for the past 3 months, and not willing to discontinue usage 3 months before and during the study duration

Trial design

Design model

Crossover

Treatments tested in this trial

  • Bead-milled microalgae

    Dietary supplement

    Consume a 400 mL drink containing 20 g protein equivalent of bead-milled microalgae

  • Non-bead-milled microalgae

    Dietary supplement

    Consume a 400 mL drink containing 20 g protein equivalent of non-bead-milled microalgae

  • Whey protein isolate

    Dietary supplement

    Consume a 400 mL drink containing 20 g protein equivalent of whey protein isolate

  • Soy protein isolate

    Dietary supplement

    Consume a 400 mL drink containing 20 g protein equivalent of soy protein isolate

  • Maltodextrin (Placebo)

    Dietary supplement

    Consume a 400 mL drink containing maltodextrin matched for the energy content of 20 g protein

Treatment groups

20 Participants
are divided into 5 treatment groups
Group A: Bead-milled microalgaeExperimental treatment 1 intervention
Group B: Non-bead-milled microalgaeActive comparator 1 intervention
Group C: Whey protein isolateActive comparator 1 intervention
Group D: Soy Protein IsolateActive comparator 1 intervention
Group E: MaltodextrinPlacebo comparator 1 intervention

Trial outcomes

Primary outcomes

1

Changes in metabolites found in plasma (plasma metabolomics)

Targeted metabolomics profiling of plasma will be conducted using liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS)

Time frame
Baseline, 15, 30, 45, 60, 90, 120, 180, 240, 300 minutes
2

Changes in metabolites found in urine (urinary metabolomics)

Targeted metabolomics profiling of urine will be conducted liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS)

Time frame
Baseline and 300 minutes

Secondary outcomes

1

Appetite

The Appetite Visual Analogue Scale (VAS) questionnaire will be administered, with participants rating five appetite-related outcomes, i.e. desire to eat, hunger, fullness, satisfaction, and prospective food consumption. Each response will be measured on a 100-mm visual analogue scale and scored from 0 to 100, with higher scores indicate a greater intensity of the outcomes being assessed, i.e. greater desire to eat, greater hunger, greater fullness, greater satisfaction, or a greater perceived amount of food that could be consumed.

Time frame
Baseline, 60, 120, 180, 240, 300 minutes

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

National University of Singapore

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: