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Mechanical Power As a Predictor for Weaning in Chronic Obstructive Pulmonary Disease Patients :Prospective Cohort Study.

ConditionMechanical Power
Trial statusNot yet recruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18-100
SponsorAssiut University

About this trial

The primary objective is to evaluate the mechanical power as a predictor of weaning of mechanical ventilation in COPD patients hospitalized in the respiratory intensive care unit of Assiut University Hospital The secondary objective is to compare between mechanical power and diaphragmatic excursion (DE) assessed by ultrasound as a predictor of weaning in these patients. Also, to investigate the association between MP and DE and mortality in these patients

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

All COPD mechanically ventilated patients admitted to respiratory intensive care unit and eligible for weaning according to European respiratory society 2016 (5).

Disqualifiers

None

Trial population

COPD patients who are mechanically ventilated in Respiratory ICU in Assiut University Hospital.

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

  • Chest ultrasound

    Other intervention

    to assess diaphragmatic excursion (DE(. M-mode was used to record the movement of the diaphragm during tidal breathing when the sampling line and diaphragm were as vertical as possible (not \< 70°). The data was measured from the first respiratory cycle at 0 min after SBT.

  • Calculation of Mechanical Power on the first day of intubation and before First trial of weaning:

    Other intervention

    Total respiratory rate (RR). Positive end-expiratory pressure (PEEP) (the external or applied PEEP) recorded, not the total PEEP, or intrinsic PEEP. The plateau pressure (Pplat) was measured during an inspiratory pause on the ventilator. Peak inspiratory pressure (Ppeak) should be obtained while the patient is relaxed, not coughing or moving in bed. MP was calculated according to Gattinoni's simplified mechanical power equation as follows (3,8): MP(J/min)=0.098×VT×RR×(Ppeak-0.5×ΔP).

Treatment groups

84 Participants
are divided into 2 treatment groups
Group A: Paients with Successful weaning from Mechanical Ventilation2 interventions
Group B: Patients with failed weaning from Mechanical Ventilation0 interventions

Trial outcomes

Primary outcomes

1

1. Evaluation the efficacy of MP as a predictor of weaning for COPD patients.

Evaluation the efficacy of MP as a predictor of weaning for COPD patients.

Time frame
2 years

Secondary outcomes

1

1-MP as a predictor of patient's mortality.

MP as a predictor of patient's mortality.

Time frame
2 years
2

2-MP and duration of hospital stay and ICU stay.

MP and duration of hospital stay and ICU stay.

Time frame
2 years
3

3-MP and ventilator induced lung injury.

THE ASSOCIATION BETWEEN VALUE OF MP and ventilator induced lung injury.

Time frame
2 years
4

4-Correlation analysis between mechanical power and other parameters of weaning: Respiratory rate, Rapid shallow breathing index, Heart Rate and Expiratory Tidal volume in evaluation of prognosis in COPD patients.

Correlation analysis between mechanical power and other parameters of weaning: Respiratory rate, Rapid shallow breathing index, Heart Rate and Expiratory Tidal volume in evaluation of prognosis in COPD patients.

Time frame
2 years

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Assiut University

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: