Mechanical Ventilation in Obese Surgical Patients
ConditionObese
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18+
SponsorThe University of Texas Medical Branch, Galveston
About this trial
The purpose of this study is to evaluate whether an intraoperative positive end-expiratory pressures (PEEP) setting strategy aimed at minimizing the mechanical power delivered to the lungs via transpulmonary pressure improves postoperative outcomes in obese patients undergoing conventional laparoscopic or robotic-assisted surgery. The objectives are to determine whether this strategy reduces immediate postoperative hypoxemia, and to assess whether it mitigates lung injury as reflected by relevant blood biomarkers.
Eligibility criteria
Qualifiers
Age ≥ 18 years;
Body Mass Index (BMI) ≥ 35 kg/m2;
Scheduled for laparoscopic surgery expected to exceed 2h (from incision to closure) under general anesthesia, as determined pre-operatively by the attending surgeon and surgical team based on typical scheduling estimates, prior experience, procedure type, planned surgical approach, and patient-specific factors.
Disqualifiers
Previous lung surgery;
Invasive mechanical ventilation for >30 minutes within the last 30 days prior to surgery;
Receipt of immunosuppressive medication (chemotherapy or radiotherapy) up to two months prior to surgery;
Neurological procedures or cardiac surgery;
Trial design
Treatments tested in this trial
- Standard PEEP (8 cmH₂O)
Treatment groups
10 Participants
are divided into 2 treatment groupsSponsors and collaborators
Source ClinicalTrials.gov