1. We collect lung tissues from patients with different ages and confirm that KLK8 expression is positively correlated with age. 2. We collect peripheral blood from patients with different ages and duration of mechanical ventilation to explore the correlation between the degree of endothelial/epithelial damage, age and duration of mechanical ventilation.
None
None
We started collecting lung tissues and peripheral blood from patients with mechanical ventilation from June 2023. All clinical samples have been collected and tested uniformly. Correlation analysis between KLK8 and age using SPSS 22.0 software will be performed, and P\<0.05 indicates a statistically significant difference. The obtained clinical data should be recorded on survey forms, and researchers should verify patient information by recording basic information such as age and gender.
Other
Prospective
mechanical ventilation
Procedure/SurgeryMechanical ventilation is machine-delivered flow of gases to both oxygenate and ventilate a patient who is unable to maintain physiological gas exchange.
6
Treatment groupsSee each treatment group below.
KLK8 concentration of lung tissue
The concentration of KLK8 in lung tissue is determined by ELISA.
Endothelial/epithelial damage index concentration in peripheral blood
The concentration of endothelial/epithelial damage index in lung tissue is determined by ELISA.
Click on the lead sponsor to view all of their trials.
