Mechanisms of Acute Kidney Injury in Severe Infections
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age30+
SponsorUppsala University Hospital
About this trial
Renal perfusion and neutrophil-mediated inflammation will be assessed in the kidney in sepsis patients with acute kidney injury using positron emission tomography. For marked water will be used for renal perfusion and a newly developed PET tracer molecule (11C-GW457427) with specific binding to neutrophil elastase which provides a measure of the amount of infiltrating neutrophils in the renal parenchyma for inflammation. The study is performed in a PET-CT camera where anatomical imaging takes place at the same time as the PET examinations.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
> 30 years
At least AKI stage 1 according to KDIGO where the last plasma creatinine is measured within 24 hours of the examination
> 30 years
No previously known kidney disease
Disqualifiers
Chronic renal failure (CKD stage >3a) or dialysis
Instability in vital functions that makes PET-CT examination unsuitable
Claustrophobia or other reasons that make the patient unable to lie still during the examination.
Pregnancy and breastfeeding
Trial population
Critically ill patients with sepsis and AKI and healthy volunteers
Trial design
Design model
Case-control
Time perspective
Prospective
Treatments tested in this trial
Positron emission tomography (PET)
RadiationAssessment of blood flow with marked water and assessment of neutrophil presence with neutrophil elastase tracer + CT
Treatment groups
15 Participants
are divided into 2 treatment groupsGroup A: Patients with sepsis and AKI1 intervention
Group B: Healthy controls1 intervention
Trial outcomes
Primary outcomes
1
Renal perfusion in patients with sepsis and acute kidney injury (AKI) measured by 15O-labeled water in dynamic positron emission tomography (PET)
vs controls
Time frame
PET performed within 10 days of AKI2
Presence of neutrophil elastase in the kidneys in patients with sepsis and acute kidney injury (AKI) by 11C-GW457427 measured with dynamic positron emission tomography (PET)
vs controls
Time frame
PET performed within days of AKISponsors and contacts
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Source ClinicalTrials.gov