Mechanisms of Resistance Exercise Training for Improved Muscle Insulin Sensitivity
ConditionResistance Training
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age30-50
SponsorMayo Clinic
About this trial
To uncover the underlying mechanisms of resistance exercise training benefits on glucose metabolism and insulin sensitivity in muscle.
Eligibility criteria
This trial accepts healthy volunteersQualifiers
Sedentary (≤30min of physical activity on ≤1 day/week)
Weight stable for ≥3 months prior to study
Disqualifiers
Active coronary artery disease or heart failure.
Participation in a structured exercise program > 1 day/week.
Abnormal liver function test results (Transaminase >2 times the upper limit of normal)
Abnormal renal function test results (calculated GFR <60 mL/min/1.73m2); If on antihypertensive, thyroid, anti-depressant or lipid lowering medication, lack of stability on the medication for the past 2 months prior to enrollment in the study
Trial design
Design model
Single group
Treatments tested in this trial
Resistance Exercise Training
Other interventionParticipants will undergo resistance exercise training 3 days a week for approximately 1 hour each day for 8 weeks.
Treatment groups
16 Participants
are divided into 1 treatment groupGroup A: Resistance Exercise TrainingExperimental treatment 1 intervention
Trial outcomes
Primary outcomes
1
Change in muscle protein synthesis
Rate of insulin-stimulated synthesis of individual proteins
Time frame
Baseline; 8 weeksSponsors and contacts
Click on the lead sponsor to view all of their trials.
Mayo Clinic
Lead sponsor
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Collaborator
Source ClinicalTrials.gov
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