This project will collect brain imaging data to quantify the effects of early visual cortex damage and visual training interventions on the structure and function of the residual visual system. Our goal is to improve understanding of the consequences of permanent visual cortex damage in humans, and to understand how visual training impacts the function of the residual visual system to restore perception.
Subjects between 21 and 80 years of age
Subjects must be residents of the United States or Canada
Subjects must exhibit unilateral stroke or stroke-like damage to primary visual cortex or its immediate afferent white matter sustained within the specified age range of 21 - 80 years (verified by MRI and/or CT scans)
Subjects with reliable visual field defects in both eyes (homonymous defects) as measured by Humphrey, MAIA, Goldmann, and/or equivalent perimetry. This deficit must be large enough to enclose a 5-deg diameter visual stimulus.
None
Cortically blind patients
Cohort
Prospective
MRI
Diagnostic testFunctional MRI scan
Identify visual areas of damage
Use fMRI scans to identify areas of damage
Characterize visual response prior to visual training
Visual responses of different brain areas spared by the patients stroke will be analyzed using a population receptive field (pRF) method.
Characterize how visual response properties in residual visual areas change following a period of visual training
Characterize how visual response properties in residual visual areas change following a period of visual training. Visual responses of different brain areas will be analyzed using a population receptive field (pRF) method.
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University of Rochester
Lead sponsor
National Institutes of Health (NIH)
Collaborator
Research to Prevent Blindness
Collaborator
National Institute of Neurological Disorders and Stroke (NINDS)
Collaborator
National Institute of Mental Health (NIMH)
Collaborator
University of Texas at Austin
Collaborator
