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Mechanisms Underlying the Protective Vascular Effects of Dietary Potassium in Humans

ConditionCardiovascular Risk Factor
Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-45
SponsorUniversity of Delaware

About this trial

Americans continue to consume high amounts of sodium. Potassium is notable for its blood pressure lowering effects but less is known regarding its effect on the vasculature. This investigation seeks to determine the role of dietary potassium on the vasculature in the presence of a high sodium diet in salt-resistant adults.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

healthy

normal blood pressure

normal resting ECG

Disqualifiers

hypertension

history of heart disease

diabetes

kidney disease

Trial design

Design model

Crossover

Treatments tested in this trial

  • Moderate Potassium/Low Sodium Diet

    Other intervention

    Consumption of 10 days of a diet moderate in potassium and low in sodium.

  • Moderate Potassium/High Sodium Diet

    Other intervention

    Consumption of 10 days of a diet moderate in potassium and high in sodium.

  • High Potassium/High Sodium Diet

    Other intervention

    Consumption of 10 days of a diet high in potassium and high in sodium.

Treatment groups

90 Participants
are divided into 3 treatment groups
Group A: Moderate Potassium/Low SodiumExperimental treatment 1 intervention
Group B: Moderate Potassium/High SodiumExperimental treatment 1 intervention
Group C: High Potassium/High SodiumExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

Conduit artery endothelial-dependent dilation

The change in flow-mediated dilation (FMD) between the 3 diets as assessed by brachial artery FMD

Time frame
on day 10 of the diet
2

Microvascular function

Cutaneous microvascular dilatory response to local heating assessed by laser Doppler flowmetry coupled with intradermal microdialysis

Time frame
on day 10 of the diet

Secondary outcomes

1

Ambulatory BP monitoring

assessed by 24-hour ambulatory blood pressure

Time frame
on day 7 and 10 of diet

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University of Delaware

Lead sponsor

National Heart, Lung, and Blood Institute (NHLBI)

Collaborator

Source ClinicalTrials.gov
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