Mechanistic Clinical Trial of Advanced Imaging for CRT

ConditionHeart Failure, Systolic

Trial statusRecruiting

Trial phaseNot applicable

Trial typeInterventional

Biological sexAll

Age20-90

SponsorUniversity of Virginia

About this trial

This is a mechanistic clinical trial with randomization to guidance for the CRT procedure using cardiac magnetic resonance (CMR) and computed tomography angiography (CTA) versus a standard procedure.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Chronic systolic HF

LVEF 35% or less

Guideline-based class I or II indication for CRT

Disqualifiers

Inability to provide informed consent

Pregnancy

Presence of metal embedded in the body due to prior accident or injury, as documented by skull films or other imaging

Cerebral aneurysm clips

Trial design

Design model

Parallel

Treatments tested in this trial

CMR/CTA Guidance for CRT
Diagnostic test
The intervention is the use of CMR and CTA to determine the optimal pacing site in the left ventricle for cardiac resynchronization therapy (CRT) and guide left ventricular lead placement.

Treatment groups

180 Participants

are divided into 2 treatment groups

Group A: InterventionExperimental treatment 1 intervention

Group B: ControlNo intervention 0 interventions

Trial outcomes

Primary outcomes

Left ventricular end-systolic volume (LVESV) improvement

Change in LVESV with cardiac resynchronization therapy (CRT)

Time frame

One Year

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

University of Virginia

Lead sponsor

Source ClinicalTrials.gov

Apply now