Medical Imaging Screening for Posterior-circulation Ischemic Stroke
ConditionEndovascular Thrombectomy
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
AgeNot listed
SponsorTianjin Huanhu Hospital
About this trial
Patients with ischemic stroke in the posterior circulation continue to have high rates of mortality and disability, even with aggressive treatment. We wanted to evaluate preoperative imaging to screen patients with a good prognosis from mechanical embolization. We assess the degree of ischemia by defining the pons-midbrain-medulla index (PMMI) and correlate the preoperative PMMI with the clinical prognosis of postoperative patients to verify the validity of PMMI in predicting the clinical prognosis of patients with embolization.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
Patient admitted from Jun. 1st 2019 to Jan. 1st 2029;
Patients with acute ischemic stroke recently；
Symptoms persisted at admission, and MRI (including DWI) confirmed acute ischemic vertebrobasilar artery occlusion in the posterior circulation:（single right or left intracranial branch of vertebral artery occlusion ; single basilar occlusion ; both two vertebral arterys and basilar artery）；
Disqualifiers
None
Trial population
All acute ischemic strvoke patients with vertebrobasilar artery occlusion.
Trial design
Design model
Cohort
Time perspective
Prospective
Treatments tested in this trial
Endovascular Therapy
Procedure/SurgeryEndovascular therapy, as an adjunct to standard stroke therapy, may be beneficial for a very select population of patients who present with an acute ischemic stroke and have a proven large, proximal occlusion on imaging. Endovascular therapy includes any one or more of the following: Intra-arterial thrombolytic therapy, aspiration, stent retrieval, or a combination of multiple mechanical devices
Treatment groups
1,000 Participants
are divided into 2 treatment groupsGroup A: Endovascular therapy1 intervention
Group B: Best medical management0 interventions
Trial outcomes
Primary outcomes
1
Modified ranking scale (mRS) at 90 days
A 0-6 scale running from perfect health without symptoms to death.
Time frame
90 daysSecondary outcomes
1
Mortality within 90 days
mortality of any causes.
Time frame
90 daysOther outcomes
1
National Institutes of Health Stroke Scale (NIHSS) scores at 90 days
The NIHSS is composed of 11 items, each of which scores a specific ability between a 0 and 4. For each item, a score of 0 typically indicates normal function in that specific ability, while a higher score is indicative of some level of impairment. The individual scores from each item are summed in order to calculate a patient's total NIHSS score. The maximum possible score is 42, with the minimum score being a 0.
Time frame
90 days2
Occurrence of periprocedural complications
Periprocedural complications include any intracranial hemorrhage, cerebral edema, brain herniation and pneumonia.
Time frame
90 days3
pc-ASPECT (posterior circulation Alberta Stroke Program Early CT score)
pc-ASPECTS is a 10-point quantitative topographic CT scan score used in patients with posterior circulation stroke.
Time frame
0 daysSponsors and contacts
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Source ClinicalTrials.gov