Medical Treatment Alone Versus Varicocelectomy Versus Varicocelectomy and Medical Treatment

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexMale
Age20-50
SponsorSouth Valley University

About this trial

A varicocele is defined as an abnormal venous dilatation and/or tortuosity of the pampiniform plexus in the scrotum. Although varicoceles are almost always and more common on the left side, up to 50% of the men with varicocele, have bilateral varicoceles.

Varicocele has a negative impact on spermatogenesis, testicular volume, Standard semen parameters, and fertilization, implantation, and embryo outcomes.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

Sub-fertile men with clinically palpable varicoceles ( unilateral or bilateral ).

Men with teratozoospermia.

Disqualifiers

Recurrent varicoceles.

Significant medical diseases as: Hepatic insufficiency.

Hypersensitivity to the drugs.

Female factor of infertility.

Trial design

Design model

Parallel

Treatments tested in this trial

  • l-carnitine

    Drug

    to compare the efficacy of medical treatment (l-carnitine and antioxidants) versus surgical treatment (varicocelectomy) versus surgical treatment and medical treatment (varicocelectomy with adjuvant medications) on pregnancy rate on varicocele related subfertility patients with isolated teratozoospermia.

Treatment groups

126 Participants
are divided into 3 treatment groups
Group A: Group of l-carnitine and antioxidantActive comparator 1 intervention
Group B: Group of varicocelectomyActive comparator 1 intervention
Group C: Group of Mixed Treatment(varicocelectomy then l-carnitine and antioxidant)Active comparator 1 intervention

Trial outcomes

Primary outcomes

1

Number of participants with Treatment of Teratozoospermia

Treatment of the male patients that suffering from abnormally shaped sperms (Teratozoospermia) by medical treatment and or subinguinal varicocelcetomy

Time frame
3 months

Secondary outcomes

Other outcomes

Sponsors and contacts

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