About this trial
This study will evaluate whether a 12-week dietary intervention can improve gut health, inflammation, and quality of life in adults with ulcerative colitis in remission.
Participants will be randomly assigned to one of three groups: a Mediterranean diet, a Mediterranean diet combined with time-restricted feeding (eating within an 8-hour window each day), or standard dietary advice. The Mediterranean diet emphasizes fruits, vegetables, whole grains, legumes, nuts, olive oil, and fish, while limiting processed foods and red meat.
The main outcome will be changes in short-chain fatty acids in stool samples, which are markers of gut health. Additional outcomes include changes in inflammation markers, gastrointestinal symptoms, and quality of life.
The results of this study may help identify effective dietary strategies to support patients with ulcerative colitis.
Eligibility criteria
Qualifiers
Adults aged 18 to 60 years
Diagnosis of ulcerative colitis
Clinical remission for at least 6 months
Fecal calprotectin < 250 µg/g in the last 3 months
Disqualifiers
Active ulcerative colitis
History of gastrointestinal surgery
Liver or kidney disease
Pregnancy
Trial design
Treatments tested in this trial
- Mediterranean Diet
- Mediterranean Diet + Time-Restricted Feeding
- Standard Dietary Advice