Mediterranean Diet and Time-Restricted Feeding in Ulcerative Colitis Remission

Trial statusRecruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age18-60
SponsorPontificia Universidad Catolica de Chile

About this trial

This study will evaluate whether a 12-week dietary intervention can improve gut health, inflammation, and quality of life in adults with ulcerative colitis in remission.

Participants will be randomly assigned to one of three groups: a Mediterranean diet, a Mediterranean diet combined with time-restricted feeding (eating within an 8-hour window each day), or standard dietary advice. The Mediterranean diet emphasizes fruits, vegetables, whole grains, legumes, nuts, olive oil, and fish, while limiting processed foods and red meat.

The main outcome will be changes in short-chain fatty acids in stool samples, which are markers of gut health. Additional outcomes include changes in inflammation markers, gastrointestinal symptoms, and quality of life.

The results of this study may help identify effective dietary strategies to support patients with ulcerative colitis.

Eligibility criteria

Qualifiers

Adults aged 18 to 60 years

Diagnosis of ulcerative colitis

Clinical remission for at least 6 months

Fecal calprotectin < 250 µg/g in the last 3 months

Disqualifiers

Active ulcerative colitis

History of gastrointestinal surgery

Liver or kidney disease

Pregnancy

Trial design

Treatments tested in this trial

  • Mediterranean Diet
  • Mediterranean Diet + Time-Restricted Feeding
  • Standard Dietary Advice

Treatment groups

45 Participants
are divided into 3 treatment groups