Health TrialsbyHealthPanel

Memory Enhancement in Aging With Closed-Loop tACS

ConditionsAgingNoninvasive Brain StimulationMemory
Trial statusNot yet recruiting
Trial phaseNot applicable
Trial typeInterventional
Biological sexAll
Age65+
SponsorBoston University Charles River Campus

About this trial

This project optimizes high-resolution tACS to improve memory in healthy older adults, advancing drug-free approaches for ADRD. We test stimulation schedules and develop an adaptive, brain-guided tACS system to strengthen memory-supporting networks.

Eligibility criteria

This trial accepts healthy volunteers

Qualifiers

65 years of age or older

normal or corrected-to-normal vision

color vision

Disqualifiers

pregnant

metal implants in head

implanted electronic devices

history of neurological problems or head injury

Trial design

Design model

Crossover

Treatments tested in this trial

  • Peak Frequency

    Device

    Device: High definition transcranial electrical current stimulation Low-intensity, noninvasive application of electrical current to the human scalp tailored to individual peak frequency with the goal of modulating levels of neuronal excitability.

  • Phase Lag

    Device

    Device: High definition transcranial electrical current stimulation Low-intensity, noninvasive application of electrical current to the human scalp tailored to individual phase lag with the goal of modulating levels of neuronal excitability.

  • Peak Frequency + Phase Lag

    Device

    Device: High definition transcranial electrical current stimulation Low-intensity, noninvasive application of electrical current to the human scalp tailored to individual peak frequency and phase lag with the goal of modulating levels of neuronal excitability.

  • Non-Adpative

    Device

    Device: High definition transcranial electrical current stimulation Low-intensity, noninvasive application of electrical current to the human scalp not tailored to individual peak frequency or phase lag with the goal of modulating levels of neuronal excitability.

Treatment groups

160 Participants
are divided into 4 treatment groups
Group A: Peak FrequencyExperimental treatment 1 intervention
Group B: Phase LagExperimental treatment 1 intervention
Group C: Peak Frequency + Phase LagExperimental treatment 1 intervention
Group D: Non-AdaptiveExperimental treatment 1 intervention

Trial outcomes

Primary outcomes

1

EEG phase locking value (PLV) during working memory retention

Phase locking value between frontotemporal EEG electrodes within the theta frequency band during the memory retention interval of the visual working memory task

Time frame
Baseline, Day 2
2

Interruption suppression measured behaviorally

Memory accuracy performance difference between interruption and control trials on the interruption working memory task

Time frame
Baseline, Day 2
3

EEG phase amplitude coupling (PAC) during working memory retention

Theta phase gamma amplitude cross-frequency coupling at temporal EEG electrodes during the memory retention interval of the visual working memory task

Time frame
Baseline, Day 2

Secondary outcomes

Other outcomes

Locations

This trial has no locations.

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Boston University Charles River Campus

Lead sponsor

Source ClinicalTrials.gov

This trial is not recruiting at the moment. You can still explore other options: