Menopausal Hormone Therapy And Left Ventricular Function
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexFemale
Age45-60
SponsorMayo Clinic
About this trial
The purpose of this study is to compare left ventricular stroke volume and heart rate responses to bursts of SNA between PMF using, and not using, MHT.
Eligibility criteria
This trial does not accept healthy volunteersQualifiers
None
Disqualifiers
Male sex
Females between STRAW+10 stages -5 and 0
PMF in STRAW+10 stage +2
PMF using oral hormone therapy
Trial population
Study participants will be recruited from various Mayo Clinic departments/clinics located at Rochester and surrounding communities.
Trial design
Design model
Other
Time perspective
Cross-sectional
Treatments tested in this trial
Menopausal Hormone Therapy
DrugTaken in accordance with standard clinical practice, administered for a minimum duration of eight weeks.
Treatment groups
50 Participants
are divided into 2 treatment groupsGroup A: Post-menopausal females using menopausal hormone therapy1 intervention
Group B: Post-menopausal females not using menopausal hormone therapy0 interventions
Trial outcomes
Primary outcomes
1
Left ventricular stroke volume
Left ventricular stroke volume is the amount of blood pumped from the left ventricle per heartbeat (mL)
Time frame
BaselineSecondary outcomes
1
Ventriculo-Arterial (VA) coupling
Ventriculo-Arterial (VA) coupling will be measured as the ratio of end-systolic elastance (Ees) to arterial elastance (Ea).
Time frame
BaselineSponsors and contacts
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Source ClinicalTrials.gov