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Metabolic Cluster Analysis in Septic Shock Patients

ConditionSeptic Shock
Trial statusRecruiting
Trial phaseNot listed
Trial typeObservational
Biological sexAll
Age18+
SponsorCorporacion Parc Tauli

About this trial

Observational study including septic shock patients within 24 hours of ICU admission, monitored with a cardiac output estimation system, with ongoing resuscitation. Hemodynamic and metabolic parameters before and after a fluid challenge (FC) will be measured.

Eligibility criteria

This trial does not accept healthy volunteers

Qualifiers

None

Disqualifiers

Age under 18 years old

Uncontrolled hemodynamic instability, defined as the need for significant changes in vasopressor support (> 10% from baseline dose) within the 15-minute period prior to, and/or during the administration of fluids.

Patients receiving continuous renal replacement therapies, since the CO values obtained from the thermodilution techniques might be potentially affected.

Trial population

Septic shock patients within the first 24 hours of ICU admission, and selected by the attending physician for performing a fluid challenge (FC) due to suspected tissue hypoperfusion.

Trial design

Design model

Cohort

Time perspective

Prospective

Treatments tested in this trial

  • Fluid challenge

    Other intervention

    Rapid infusion (\< 15 minutes) of a fluid bolus of crystalloids (200 to 500cc)

Treatment groups

120 Participants
are divided into 1 treatment group
Group A: Septic shock1 intervention

Trial outcomes

Primary outcomes

1

VO2-response

Percentage increase in VO2 as results of the fluid challenge

Time frame
30 minutes

Secondary outcomes

1

Organ failure

Assessment of the SOFA score at day 1, 2 and 4

Time frame
4 days
2

Mortality

Mortality within the first 28 days

Time frame
28 days

Other outcomes

Sponsors and contacts

Click on the lead sponsor to view all of their trials.

Corporacion Parc Tauli

Lead sponsor

Source ClinicalTrials.gov
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